IQSEC1 (Vector pUC, Accession No. BC010267)

Length: 2445 Sequence: atgctagaac gaaagtatgg ggggcgcctg gtaacccgcc atgcggcccg caccatccag acggcgtttc gccagtacca gatgaacaag aacttcgagc gcttgcgcag ctccatgtca gagaaccgca tgtcacgccg gattgtgctg tccaacatga ggatgcagtt ctcctttgag gggcctgaga aagtgcacag ctcctacttc gaggggaagc aggtctcagt gactaacgac ggctcccagc tgggagccct ggtgtcccct gagtgtggtg acctcagcga gcccaccacc ctcaagtctc cggccccctc cagtgacttt gcggacgcca tcaccgagct ggaggacgcc ttctctaggc aagtgaaatc actggccgag tccatcgacg atgccctcaa ctgccgcagc ctgcacactg aggaggcacc ggccctggat gcggcgcggg cccgggacac cgaaccccag acagccctgc acggcatgga ccaccgcaaa ctggacgaga tgacggcctc gtacagtgat gtcaccctgt acatcgatga ggaggagctg tcgccccctc tgcccctctc gcaggcaggg gaccggccgt ccagcaccga gtcggacctg cggctacggg ctgggggcgc agccccagac tactgggccc tggcccacaa agaggacaag gctgacacgg acacgagctg ccggagcacg ccgtcgctgg agcggcagga gcagcggctg cgggtggagc atctgccgct gctcaccatc gagccaccca gcgacagctc tgtggacctt agtgaccgct cggagcgggg gtcactcaag aggcagagtg cttacgagcg cagccttggc gggcagcagg gcagtcccaa gcatggtccc cacagcggcg cccccaagag cctcccccgg gaggagcctg agttgcggcc ccggcccccc aggcccctgg acagccactt ggccatcaat ggctcagcca accggcagag caagtctgag tcggactact cagacggtga caatgacagc atcaacagca cgtccaactc caacgatacc atcaactgca gctccgagtc atcgtcccgt gacagcctgc gggagcagac gctcagcaag cagacctacc acaaggaggc ccgcaacagc tgggactcgc ctgcctttag caacgatgtc atccgcaaga ggcactaccg catcggcctg aacctcttca acaagaagcc tgagaaggga gtccagtacc tcatcgagcg tggctttgtg cccgacacgc ccgtcggggt ggcccacttc ctgctgcagc gcaagggcct cagccggcag atgatcggcg agttcctggg caaccggcag aagcagttca accgtgacgt gctcgactgc gtcgtggacg agatggactt ctctaccatg gagctggatg aggccctcag gaaattccag gcgcacatcc gtgtccaagg ggaggctcag aaagtggagc ggctcataga ggcgttcagc cagcgctact gcatctgcaa ccctggggtg gtgcggcaat tccggaaccc agacaccatt ttcatcctgg ccttcgccat catcctgctg aacaccgaca tgtacagccc caatgtcaag cccgagcgga aaatgaagct agaggacttc atcaagaacc tccgaggtgt ggacgatggt gaggacattc cccgtgagat gctgatgggg atctatgaac ggatccgtaa gcgagagcta aagaccaatg aggaccatgt gtcccaggtg cagaaggtgg agaagctcat tgtggggaaa aagccgatcg gatccctgca tcccgggctc ggctgtgtgc tctctctgcc ccaccgtcgg ttggtctgct actgccggct ctttgaggtt ccagacccaa acaagcccca gaaactcgga ctacaccagc gagaaatctt cctgttcaac gacctcctgg tggtcaccaa gatcttccag aagaagaaga actcggtgac gtacagcttc cgacagtcct tctccttgta cggcatgcag gtcctgctct tcgagaacca gtactacccc aatggcatcc ggctcacctc gtctgtcccc ggagcagata tcaaagtgtt aataaacttc aacgccccca accctcaaga ccggaagaaa ttcaccgatg acctgcggga gtccattgcg gaagtccaag agatggagaa gcacaggata gagtcggagc tcgagaagca gaaaggcgtc gtgcggccca gcatgtccca gtgctctagc ctcaaaaagg agtcgggcaa cggaacactg agccgggcct gcctggacga cagctatgcc agcggtgagg gcctcaagcg cagcgccctc agcagctccc tgcgggacct ctcggaagcc ggggtccatc Protein function: Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:24058294, PubMed:11226253). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin (PubMed:16461286). Involved in neuronal development (Probable). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors. [The UniProt Consortium]