IPMK (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 1251 Sequence: atggcaacag agccaccatc ccccctccgg gtcgaggcgc cgggcccccc agaaatgcgg acctcaccgg cgatcgagtc cacccctgag ggcaccccgc agccggcggg cggcagactc cgcttcctca acggctgcgt gcccctctcg catcaggtgg ccgggcacat gtacgggaag gacaaagtgg gtatactgca acatccagat ggcacagttt tgaaacagtt acaaccacct ccaaggggcc caagagagct ggaattctat aatatggttt atgctgctga ctgttttgat ggtgttcttc tagagctacg aaaatatttg ccaaaatatt atggcatctg gtcacctccc actgcaccaa acgatttata cctaaaactg gaagatgtga cccataaatt taataagccc tgtataatgg atgtaaagat agggcaaaaa agctatgatc cttttgcctc atctgagaag attcagcaac aggtcagcaa gtacccatta atggaagaga ttgggttctt ggtgcttggc atgagggttt atcatgttca ttccgatagc tatgagacag aaaaccagca ttacggaaga agcttaacaa aagaaactat aaaggatgga gtctccagat tttttcataa tgggtactgc ttaagaaaag atgctgttgc tgccagtatt cagaagattg agaaaattct gcagtggttt gaaaaccaga agcagcttaa tttttacgca agttcattac tctttgttta tgaaggttca tctcagccaa ccactacaaa attgaatgac agaactttgg cagaaaagtt tttgtccaaa ggacaactgt cagacacaga agtactagag tacaataata actttcatgt gttaagttcc acagctaatg gaaaaataga gtcttcagtg ggcaaaagct tgtccaagat gtatgcgcgt cacaggaaaa tatatacaaa aaagcatcac agtcagactt cattgaaagt tgaaaatctg gagcaagaca atgggtggaa aagcatgtca caggaacatt taaatggaaa tgtactttcc caactggaaa aagttttcta ccatcttccc actggttgcc aagagattgc tgaagtagaa gtgcgaatga tagattttgc tcatgtgttc cctagcaaca caatagatga gggatatgtt tatgggctaa agcatttaat ttctgtactt cgaagtattt tagacaattg Protein function: Inositol phosphate kinase with a broad substrate specificity (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30420721, PubMed:30624931). Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30624931). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed:12223481). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5- trisphosphate (PubMed:30420721, PubMed:28882892). Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase. Essential for activated phospho- MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610). Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6). [The UniProt Consortium]