IFITM2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 399 Sequence: atgaaccaca ttgtgcaaac cttctctcct gtcaacagcg gccagcctcc caactacgag atgctcaagg aggagcagga agtggctatg ctgggggcgc cccacaaccc tgctcccccg acgtccaccg tgatccacat ccgcagcgag acctccgtgc ctgaccatgt cgtctggtcc ctgttcaaca ccctcttcat gaacacctgc tgcctgggct tcatagcatt cgcctactcc gtgaagtcta gggacaggaa gatggttggc gacgtgaccg gggcccaggc ctatgcctcc accgccaagt gcctgaacat ctgggccctg attttgggca tcttcatgac cattctgctc gtcatcatcc cagtgttggt cgtccaggcc Protein function: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. [The UniProt Consortium]