IFFO1 (Vector pUC, Accession No. BC110387)

Length: 1692 Sequence: ATGAATCCGT TATTCGGCCC CAACCTCTTC CTCCTGCAGC AGGAGCAGCA GGGCCTGGCC GGGCCACTGG GGGACTCACT GGGAGGCGAC CACTTCGCCG GGGGAGGAGA CTTGCCCCCG GCGCCTCTCT CGCCGGCCGG CCCTGCTGCC TACTCGCCGC CCGGGCCGGG CCCGGCCCCG CCTGCCGCCA TGGCCCTCCG CAATGACCTG GGCTCCAACA TCAACGTGCT CAAGACCCTG AACCTCCGGT TCCGCTGCTT CCTGGCCAAG GTGCATGAGC TGGAGCGCCG GAACCGGCTG TTGGAGAAGC AACTGCAGCA AGCGCTGGAG GAGGGTAAGC AGGGCCGGCG GGGCCTGGGT CGTCGCGACC AGGCAGTGCA GACCGGCTTC GTCAGCCCCA TCCGGCCCCT GGGGCTGCAG CTGGGCGCCC GGCCGGCCGC TGTCTGCAGC CCTTCGGCGC GCGTGCTGGG CTCGCCCGCG CGCTCCCCGG CCGGCCCCCT CGCGCCCTCC GCGGCCAGCC TCTCGTCGTC CTCCACCTCC ACCTCCACCA CCTATTCCTC GTCGGCCCGC TTCATGCCCG GCACCATCTG GTCGTTCTCG CACGCCCGCC GGCTCGGGCC GGGACTGGAG CCCACTCTGG TGCAAGGGCC TGGCTTGTCG TGGGTGCACC CGGATGGGGT GGGCGTCCAG ATCGACACCA TCACGCCCGA GATCCGCGCT CTCTACAACG TGCTGGCCAA AGTGAAGCGG GAGCGGGACG AGTACAAGCG GAGGTGGGAA GAGGAGTACA CGGTGCGGAT CCAGCTGCAA GACCGTGTAA ATGAGCTCCA GGAGGAAGCC CAGGAGGCTG ATGCCTGCCA GGAGGAGCTG GCACTGAAGG TGGAACAGTT GAAGGCTGAG CTGGTGGTCT TCAAGGGGCT CATGAGTAAC AACCTGTCGG AGCTGGACAC CAAGATCCAG GAGAAAGCCA TGAAGGTGGA TATGGACATC TGCCGCCGCA TCGACATCAC CGCCAAGCTC TGCGATGTGG CTCAGCAGCG CAACTGCGAG GACATGATCC AGATGTTCCA GAAGAAGCTG TTCCCATCCA TGGGGGGGCG GAAGCGGGAG CGCAAGGCTG CCGTCGAGGA GGACACCTCC CTGTCGGAGA GTGAGGGGCC CCGCCAGCCC GATGGGGATG AGGAGGAGAG CACAGCCCTC AGCATCAACG AGGAGATGCA GCGCATGCTC AACCAGCTGA GGGAGTATGA TTTTGAGGAC GACTGTGACA GCCTGACTTG GGAGGAGACT GAGGAGACCC TGCTGCTTTG GGAGGATTTC TCAGGCTATG CCATGGCAGC TGCAGAGGCC CAGGGAGAGC AGCAGGAAGA TAGCCTGGAG AAGGTGATTA AAGATACGGA GTCCCTGTTC AAAACCCGGG AGAAGGAGTA TCAGGAGACC ATTGACCAGA TAGAGCTGGA GTTGGCCACG GCCAAGAACG ACATGAACCG GCACCTGCAC GAGTACATGG AGATGTGCAG CATGAAGCGC GGCCTGGACG TGCAGATGGA GACCTGCCGC CGGCTCATCA CCCAGTCTGG AGACCGAAAG TCTCCTGCTT TCACTGCGGT CCCGCTTAGC GACCCGCCGC CGCCGCCAAG CGAGGCTGAG GACTCCGATC GCGATGTCTC ATCTGACAGC TCCATGAGAT Protein function: Nuclear matrix protein involved in the immobilization of broken DNA ends and the suppression of chromosome translocation during DNA double-strand breaks (DSBs) (PubMed:31548606). Interacts with the nuclear lamina component LMNA, resulting in the formation of a nucleoskeleton that relocalizes to the DSB sites in a XRCC4-dependent manner and promotes the immobilization of the broken ends, thereby preventing chromosome translocation (PubMed:31548606). Acts as a scaffold that allows the DNA repair protein XRCC4 and LMNA to assemble into a complex at the DSB sites (PubMed:31548606). [The UniProt Consortium]