HYAL3 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1254 Sequence: atgaccacgc aactgggccc agccctggtg ctgggggtgg ccctgtgcct gggttgtggc cagcccctac cacaggtccc tgaacgcccc ttctctgtgc tgtggaatgt accctcagca cactgtgagg cccgctttgg tgtgcacctg ccactcaatt ctctgggcat catagccaac cgtggccagc attttcacgg tcagaacatg accattttct acaagaacca actcggcctc tatccctact ttggacccag gggcacagct cacaatgggg gcatccccca ggctttgccc cttgaccgcc acctggcact ggctgcctac cagatccacc acagcctgag acctggcttt gctggcccag cagtgctgga ttgggaggag tggtgtccac tctgggctgg gaactggggc cgccgccgag cttatcaggc agcctcttgg gcttgggcac agcaggtatt ccctgacctg gaccctcagg agcagctcta caaggcctat actggctttg agcaggcggc ccgtgcactg atggaggata cgctgcgggt ggcccaggca ctacggcccc atggactctg gggcttctat cactacccag cctgtggcaa tggctggcat agtatggctt ccaactatac cggccgctgc catgcagcca cccttgcccg caacactcaa ctgcattggc tctgggccgc ctccagtgcc ctcttcccca gcatctacct cccacccagg ctgccacctg cccaccacca ggcctttgtc cgacatcgcc tggaggaggc cttccgtgtg gcccttgttg ggcaccgaca tcccctgcct gtcctggcct atgtccgcct cacacaccgg agatctggga ggttcctgtc ccaggatgac cttgtgcagt ccattggtgt gagtgcagca ctaggggcag ccggcgtggt gctctggggg gacctgagcc tctccagctc tgaggaggag tgctggcatc tccatgacta cctggtggac accttgggcc cctatgtgat caatgtgacc agggcagcga tggcctgcag tcaccagcgg tgccatggcc acgggcgctg tgcccggcga gatccaggac agatggaagc ctttctacac ctgtggccag acggcagcct tggagattgg aagtccttca gctgccactg ttactggggc tgggctggcc ccacctgcca ggagcccagg cctgggccta aagaagcagt Protein function: Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro. [The UniProt Consortium]