HSPB11 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 435 Sequence: atgagaaaaa ttgatctctg tctgagctct gaagggtccg aagtgatttt agctacatca agtgatgaaa aacacccacc tgaaaatatc attgatggga atccagaaac gttttggacc accacaggaa tgtttcccca ggaattcatt atttgtttcc acaaacatgt aaggattgaa aggcttgtaa tccaaagtta ctttgtacag accttgaaga ttgaaaaaag cacgtctaaa gagccagttg attttgagca atggattgaa aaagatttgg tacacacaga ggggcagctt caaaatgaag aaattgtggc acatgatggc tccgctactt acttgagatt cattattgta tcagcctttg atcattttgc atctgtgcat agcgtttctg cagaaggaac agtagtctca aatctttcct Protein function: Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation. [The UniProt Consortium]