HORMAD2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 924 Sequence: atggccactg ctcagctttc tcactgcatc acaatacaca aggcttctaa ggaaacagtt ttcccatccc aaatcactaa tgagcatgag tcattgaaaa tggtgaagaa actttttgct acttccatct catgtataac atacctaagg ggcctgtttc cagagagctc ttatggagaa cgccatttgg atgacctcag tttaaaaatc ctccgagaag ataaaaaatg tcccgggtca ctgcatatta tcagatggat tcaaggttgt tttgatgctt tggaaaagag atacctacgt atggcagtac tgacacttta cacagatccc atgggatctg agaaggtgac tgagatgtac cagttcaaat tcaaatacac gaaagaagga gccactatgg attttgacag tcatagcagc agtacaagct ttgaaagtgg aacaaacaat gaagatatta agaaagccag tgttctactg atccgtaaat tgtatatact gatgcaggac cttgagccac ttcctaataa tgttgtactt actatgaaac tccactacta taatgcagtg accccacatg attaccaacc cctcggtttt aaagaagggg taaattcaca cttcctgctg tttgacaagg agcctatcaa cgtgcaagtg ggatttgtct ccactggctt tcatagcatg aaagtaaaag tcatgacaga ggctacaaaa gtgattgatt tggagaacaa tctgtttcgg gagaacagca ctactgagat cgcccatcag ggtctagact gtgatgagga agaagaatgc aatgaccata ttcaaagaat gaattttgtg tgcagtcagc aaagttctga gtgctccagg aagaagagga aggtcagtga accagtgaag gtcttcatcc ctaacagaaa Protein function: Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid- pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break- independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation. [The UniProt Consortium]