HORMAD1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 1185 Sequence: atggccactg cccagttgca gaggactccc atgagtgcac tggtatttcc caataagata tcaactgaac accagtcttt ggtgttagtg aagaggcttc tagcagtttc agtatcctgt atcacgtatt tgaggggaat attcccagaa tgcgcttatg gaacaagata tctagatgat ctttgtgtca aaatactgag agaagataaa aattgcccag gatctacaca gttagtgaaa tggatgctag gatgttatga tgctttacag aaaaaatatc taaggatggt tgttctagct gtatacacaa acccagaaga tcctcagaca atttcagaat gttaccaatt caaattcaaa tacaccaata atggaccact catggacttc ataagtaaaa accaaagcaa cgaatctagc atgttgtcta ctgacaccaa gaaagcaagc attctcctca ttcgcaagat ttatatccta atgcaaaatc tggggccttt acctaatgat gtttgtttga ccatgaaact tttttactat gatgaagtta cacccccaga ttaccagcct cccggtttta aggatggtga ttgtgaagga gttatatttg aaggggaacc tatgtattta aatgtgggag aagtctcaac accttttcac atcttcaaag taaaagtgac cactgagaga gaacgaatgg aaaatattga ctcaactata ctatcaccaa aacaaataaa aacaccattt caaaaaatcc tgagggacaa agatgtagaa gatgaacagg agcattatac aagtgatgat ttggacattg aaactaaaat ggaagaacag gaaaaaaacc ctgcatcttc tgaacttgaa gaaccaagtt tagtttgtga ggaagatgaa attatgaggt ctaaagaaag tccagatctt tctatttctc attctcaggt tgagcagtta gtcaataaaa catctgaact tgatatgtct gaaagcaaaa caagaagtgg aaaagtcttt cagaataaaa tggcaaatgg aaatcaacca gtaaaatctt ccaaagaaaa tcggaagaga agtcaacatg aatctgggag aatagtcctc catcactttg attcttctag tcaagagtca gtgccaaaaa ggagaaagtt tagtgaacca aaggaacata Protein function: Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. [The UniProt Consortium]