HOMER3 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1086 Sequence: atgtccacag ccagggagca gccaatcttc agcacacggg cgcacgtgtt ccaaattgac ccagccacca agcgaaactg gatcccagcg ggcaagcacg cactcactgt ctcctatttc tacgatgcca cccgcaatgt gtaccgcatc atcagcatcg gaggcgccaa ggccatcatc aacagcactg tcactcccaa catgaccttc accaaaactt cccagaagtt cgggcagtgg gccgacagtc gcgccaacac agtctacggc ttgggctttg cctctgaaca gcatctgaca cagtttgccg agaagttcca ggaagtgaag gaagcagcca ggctggccag ggagaaatct caggatggcg gggagctcac cagtccagcc ctggggctcg cctcccacca ggtgcccccg agccctctcg tcagtgccaa cggccccggc gaggaaaaac tgttccgcag ccagagcgct gatgcccccg gccccacaga gcgcgagcgg ctaaagaaga tgttgtctga gggctccgtg ggcgaggtac agtgggaggc cgagtttttc gcactgcagg acagcaacaa caagctggca ggcgccctgc gagaggccaa cgccgccgca gcccagtgga ggcagcagct ggaggctcag cgtgcagagg ccgagcggct gcggcagcgg gtggctgagc tggaggctca ggcagcttca gaggtgaccc ccaccggtga gaaggagggg ctgggccagg gccagtcgct ggaacagctg gaagctctgg tgcaaaccaa ggaccaggag attcagaccc tgaagagtca gactgggggg ccccgcgagg ccctggaggc tgccgagcgt gaggagactc agcagaaggt gcaggacctg gagacccgca atgcggagtt ggagcaccag ctgcgggcga tggagcgcag cctggaggag gcacgggcag agcgggagcg ggcgcgggct gaggtgggcc gggcagcgca gctgctggac gtcaggctgt ttgagctgag tgagctgcgt gagggcctgg cccgcctggc tgaggctgcg Protein function: Postsynaptic density scaffolding protein. Binds and cross- links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER- associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). [The UniProt Consortium]