HLA-F (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1329 Sequence: atggcgcccc gaagcctcct cctgctgctc tcaggggccc tggccctgac cgatacttgg gcaggctccc actccttgag gtatttcagc accgctgtgt cgcggcccgg ccgcggggag ccccgctaca tcgccgtgga gtacgtagac gacacgcaat tcctgcggtt cgacagcgac gccgcgattc cgaggatgga gccgcgggag ccgtgggtgg agcaagaggg gccgcagtat tgggagtgga ccacagggta cgccaaggcc aacgcacaga ctgaccgagt ggccctgagg aacctgctcc gccgctacaa ccagagcgag gctgggtctc acaccctcca gggaatgaat ggctgcgaca tggggcccga cggacgcctc ctccgcgggt atcaccagca cgcgtacgac ggcaaggatt acatctccct gaacgaggac ctgcgctcct ggaccgcggc ggacaccgtg gctcagatca cccagcgctt ctatgaggca gaggaatatg cagaggagtt caggacctac ctggagggcg agtgcctgga gttgctccgc agatacttgg agaatgggaa ggagacgcta cagcgcgcag atcctccaaa ggcacacgtt gcccaccacc ccatctctga ccatgaggcc accctgaggt gctgggccct gggcttctac cctgcggaga tcacgctgac ctggcagcgg gatggggagg aacagaccca ggacacagag cttgtggaga ccaggcctgc aggggatgga accttccaga agtgggccgc tgtggtggtg ccttctggag aggaacagag atacacatgc catgtgcagc acgaggggct gccccagccc ctcatcctga gatgggagca gtctccccag cccaccatcc ccatcgtggg catcgttgct ggccttgttg tccttggagc tgtggtcact ggagctgtgg tcgctgctgt gatgtggagg aagaagagct cagatagaaa cagagggagc tactctcagg ctgcagccta ctcagtggtc agcggactct tgatgataac atggtggtca agcttatttc tcctgggggt gctcttccaa ggatatttgg gctgcctccg gagtcacagt gtcttgggcc gccggaaggt gggtgacatg tggatcttgt tttttttgtg gctgtggaca tctttcaaca ctgccttctt ggccttgcaa agccttcgct ttggcttcgg ctttaggagg ggcaggagct tccttcttcg ttcttggcac catcttatga aaagggtcca gattaagatt Protein function: Non-classical major histocompatibility class Ib molecule postulated to play a role in immune surveillance, immune tolerance and inflammation. Functions in two forms, as a heterotrimeric complex with B2M/beta-2 microglobulin and a peptide (peptide-bound HLA-F-B2M) and as an open conformer (OC) devoid of peptide and B2M (peptide-free OC). In complex with B2M, presents non-canonical self-peptides carrying post- translational modifications, particularly phosphorylated self-peptides. Peptide-bound HLA-F-B2M acts as a ligand for LILRB1 inhibitory receptor, a major player in maternal-fetal tolerance. Peptide-free OC acts as a ligand for KIR3DS1 and KIR3DL2 receptors (PubMed:28636952). Upon interaction with activating KIR3DS1 receptor on NK cells, triggers NK cell degranulation and anti-viral cytokine production (PubMed:27455421). Through interaction with KIR3DL2 receptor, inhibits NK and T cell effector functions (PubMed:24018270). May interact with other MHC class I OCs to cross-present exogenous viral, tumor or minor histompatibility antigens to cytotoxic CD8+ T cells, triggering effector and memory responses (PubMed:23851683). May play a role in inflammatory responses in the peripheral nervous system. Through interaction with KIR3DL2, may protect motor neurons from astrocyte- induced toxicity (PubMed:26928464). [The UniProt Consortium]