HLA-DRB3 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pU

Length: 801 Sequence: atggtgtgtc tgaagctccc tggaggctcc agcttggcag cgttgacagt gacactgatg gtgctgagct cccgactggc tttcgctggg gacacccgac cacgtttctt ggagctgcgt aagtctgagt gtcatttctt caatgggacg gagcgggtgc ggtacctgga cagatacttc cataaccagg aggagttcct gcgcttcgac agcgacgtgg gggagtaccg ggcggtgacg gagctggggc ggcctgtcgc cgagtcctgg aacagccaga aggacctcct ggagcagaag cggggccggg tggacaatta ctgcagacac aactacgggg ttggtgagag cttcacagtg cagcggcgag tccatcctca ggtgactgtg tatcctgcaa agacccagcc cctgcagcac cacaacctcc tggtctgctc tgtgagtggt ttctatccag gcagcattga agtcaggtgg ttccggaacg gccaggaaga gaaggctggg gtggtgtcca cgggcctgat ccagaatgga gactggacct tccagaccct ggtgatgcta gaaacagttc ctcggagtgg agaggtttac acttgccaag tggagcaccc aagcgtaacg agcgctctca cagtggaatg gagagcacgg tctgaatctg cacagagcaa gatgctgagt ggagtcgggg gctttgtgct gggcctgctc ttccttgggg ccgggctgtt catctacttc aggaatcaga aaggacactc tggacttcag ccaacaggat tcctgagctg Protein function: A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA- DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB3-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells. Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes (PubMed:2788702, PubMed:2463305, PubMed:16148104, PubMed:19531622, PubMed:20368442, PubMed:19830726, PubMed:23569328, PubMed:22929521, PubMed:30282837, PubMed:31020640, PubMed:31333679, PubMed:31308093). In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor- resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins. Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance. The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self- peptides. The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules. [The UniProt Consortium]