HIPK1 (Vector pUC, Accession No. BC036057)

Length: 2451 Sequence: atggttttga tgtttcagat tcgttatatt tcacaaacac aaggcttgcc agctgaatat cttctcagtg ccggaacaaa aacaaccagg tttttcaaca gagatcctaa tttggggtac ccactgtgga ggcttaagac acctgaagaa catgaactgg agactggaat aaaatcaaaa gaagctcgga agtacatttt taattgctta gatgacatgg ctcaggtgaa tatgtctacg gacctggagg gaacagacat gttggcagag aaggcagacc gaagagaata cattgatctg ttaaagaaaa tgctcacaat tgatgcagat aagagaatta cccctctaaa aactcttaac catcagtttg tgacaatgac tcaccttttg gattttccac atagcaatca tgttaagtct tgttttcaga acatggagat ctgcaagcgg agggttcaca tgtatgatac agtgagtcag atcaagagtc ccttcactac acatgttgcc ccaaatacaa gcacaaatct aaccatgagc ttcagcaatc agctcaatac agtgcacaat caggccagtg ttctagcttc cagttctact gcagcagctg ctactctttc tctggctaat tcagatgtct cactactaaa ctaccagtca gctttgtacc catcatctgc tgcaccagtt cctggagttg cccagcaggg tgtttccttg cagcctggaa ccacccagat ttgcactcag acagatccat tccaacagac atttatagta tgtccacctg cgtttcaaac tggactacaa gcaacaacaa agcattctgg attccctgtg aggatggata atgctgtacc aattgtaccc caggcaccag ctgctcagcc actacagatt cagtcaggag ttctcacgca gggaagctgt acaccactaa tggtagcaac tctccaccct caagtagcca ccatcacacc gcagtatgcg gtgcccttta ctctgagctg cgcagccggc cggccggcgc tggttgaaca gactgccgct gtactgcagg cgtggcctgg agggactcag caaattctcc tgccttcaac ttggcaacag ttgcctgggg tagctctaca caactctgtc cagcccacag caatgattcc agaggccatg gggagtggac agcagctagc tgactggagg aatgcccact ctcatggcaa ccagtacagc actatcatgc agcagccatc cttgctgact aaccatgtga cattggccac tgctcagcct ctgaatgttg gtgttgccca tgttgtcaga caacaacaat ccagttccct cccttcgaag aagaataagc agtcagctcc agtctcttcc aagtcctctc tagatgttct gccttcccaa gtctattctc tggttgggag cagtcccctc cgcaccacat cttcttataa ttccttggtc cctgtccaag atcagcatca gcccatcatc attccagata ctcccagccc tcctgtgagt gtcatcacta tccgaagtga cactgatgag gaagaggaca acaaatacaa gcccagtagc tctggactga agccaaggtc taatgtcatc agttatgtca ctgtcaatga ttctcctgac tctgactctt ctttgagcag cccttattcc actgataccc tgagtgctct ccgaggcaat agtggatccg ttttggaggg gcctggcaga gttgtggcag atggcactgg cacccgcact atcattgtgc ctccactgaa aactcagctt ggtgactgca ctgtagcaac ccaggcctca ggtctcctga gcaataagac taagccagtc gcttcagtga gtgggcagtc atctggatgc tgtatcaccc ccacagggta tcgagctcaa cgcgggggga ccagtgcagc acaaccactc aatcttagcc agaaccagca gtcatcggtg gctccaacct cacaggagag aagcagcaac ccagcccccc gcaggcagca ggcgtttgtg gcccctctct cccaagcccc ctacaccttc cagcatggca gcccgctaca ctcgacaggg cacccacacc ttgccccggc ccctgctcac ctgccaagcc aggctcatct gtatacgtat gctgccccga cttctgctgc tgcactgggc tcaaccagct ccattgctca tcttttctcc ccacagggtt cctcaaggca tgctgcagcc tataccactc accctagcac tttggtgcac caggtccctg tcagtgttgg gcccagcctc ctcacttctg ccagcgtggc ccctgctcag taccaacacc agtttgccac ccaatcctac attgggtctt cccgaggctc aacaatttac actggatacc cgctgagtcc taccaagatc agccagtatt cctacttata Protein function: Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:24559171). [The UniProt Consortium]