HEY1 (Vector pUC, Accession No. BC001873)

Length: 915 Sequence: atgaagcgag ctcaccccga gtacagctcc tcggacagcg agctggacga gaccatcgag gtggagaagg agagtgcgga cgagaatgga aacttgagtt cggctctagg ttccatgtcc ccaactacat cttcccagat tttggccaga aaaagacgga gaggaataat tgagaagcgc cgacgagacc ggatcaataa cagtttgtct gagctgagaa ggctggtacc cagtgctttt gagaagcagg gatctgctaa gctagaaaaa gccgagatcc tgcagatgac cgtggatcac ctgaaaatgc tgcatacggc aggagggaaa ggttactttg acgcgcacgc ccttgctatg gactatcgga gtttgggatt tcgggaatgc ctggcagaag ttgcgcgtta tctgagcatc attgaaggac tagatgcctc tgacccgctt cgagttcgac tggtttcgca tctcaacaac tacgcttccc agcgggaagc cgcgagcggc gcccacgcgg gcctcggaca cattccctgg gggaccgtct tcggacatca cccgcacatc gcgcacccgc tgttgctgcc ccagaacggc cacgggaacg cgggcaccac ggcctcaccc acggaaccgc accaccaggg caggctgggc tcggcacatc cggaggcgcc tgctttgcga gcgcccccta gcggcagcct cggaccggtg ctccctgtgg tcacctccgc ctccaaactg tcgccgcctc tgctctcctc agtggcctcc ctgtcggcct tccccttctc tttcggctcc ttccacttac tgtctcccaa tgcactgagc ccttcagcac ccacgcaggc tgcaaacctt ggcaagccct atagaccttg ggggacggag atcggagctt Protein function: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3 (PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). [The UniProt Consortium]