HCFC1 (Vector pENTR223.1, Accession No. BC063435)

Length: 1287 Sequence: atggcttcgg ccgtgtcgcc cgccaacttg ccagcggtgc ttctgcagcc ccgctggaag cgagtggtgg gctggtcggg tccggtgcca cggccccgcc acggccaccg cgccgtggcc atcaaggagc tcatcgtggt gtttggcggc ggcaacgagg gaatagtgga cgaactgcac gtgtacaaca cggcaaccaa ccagtggttc atcccagccg tgagggggga cattccccct gggtgtgcag cctatggctt cgtgtgtgac gggactcgcc tcctggtgtt tggtgggatg gtggagtatg ggaaatacag caatgacctc tacgaactcc aggcgagccg gtgggagtgg aagagactca aagcaaagac gcccaaaaac gggccccctc cgtgtcctcg actcgggcac agcttctccc ttgtgggcaa caaatgctac ctgtttgggg gtctggccaa tgatagcgag gacccaaaga acaacattcc aaggtacctg aatgacttat atatcctgga attacggcca ggctctggag tggtagcctg ggacattccc atcacttacg gggtcctacc accaccccgg gagtcacata ctgccgtggt ctacaccgaa aaagacaata agaagtccaa gctggtgatc tacggcggga tgagtggctg caggctgggg gacctgtgga ccctagatat tgacaccctg acgtggaata agcccagtct cagcggggtg gcgcctcttc ctcgcagtct ccactcggca accaccatcg gaaataaaat gtacgtgttt ggtggctggg tgcctctcgt catggatgac gtcaaagtgg ccacacacga gaaggagtgg aagtgtacca acacgctggc ttgtctcaac ctggatacca tggcctggga gaccatcctg atggatacac tggaggacaa catcccccgt gctcgggctg gccactgcgc agtcgccatc aacacccgcc tgtacatttg gagtgggcgt gacggctacc gcaaggcctg gaacaaccag gtctgctgca aggacctctg gtacctagag acagaaaagc caccaccccc agcccgagta caactggtac gcgccaacac caactccctg gaggtgagct ggggggcagt ggcaacagcc gacagctacc ttctccagct ccagaaatat gacattcctg ccacggctgc tactgccacc tcccctacac ccaatccggt cccatctgtg cctgccaacc ctcccaagag Protein function: Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2, represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). [The UniProt Consortium]