HBXIP (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 522 Sequence: atggagccag gtgcaggtca cctcgacggt caccgcgcgg ggagcccaag ccttcgtcag gctctgtgcg acggaagcgc agtgatgttt tccagtaaag aacgcggacg ttgcaccgtg atcaattttg tccctttgga ggcgccgtta cggtccacgc cccgctcgcg tcaagtgact gaggcctgtg gtggagaagg acgtgccgtg ccgctgggtt ctgagccgga gtggtcggtg ggtgggatgg aggcgacctt ggagcagcac ttggaagaca caatgaagaa tccctccatt gttggagtcc tgtgcacaga ttcacaagga cttaatctgg gttgccgcgg gaccctgtca gatgagcatg ctggagtgat atctgttcta gcccagcaag cagctaagct aacctctgac cccactgata ttcctgtggt gtgtctagaa tcagataatg ggaacattat gatccagaaa cacgatggca tcacggtggc agtgcacaaa atggcctctt Protein function: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication. [The UniProt Consortium]