HBS1L (Vector pUC, Accession No. BC001465)

Length: 2055 Sequence: atggcccggc atcggaatgt tcgaggctat aactacgatg aagattttga agatgatgat ctctacggcc agtctgtaga ggatgattat tgtatttcgc cgtcaacagc tgctcagttt atttattcac ggcgtgacaa accttccgtt gagcctgtgg aagaatatga ttatgaagat ctgaaagaat cttccaattc tgtttcaaac catcagctca gtggatttga tcaagctcgt ctttattcat gccttgatca catgagagag gtacttggag atgctgtgcc agatgaaata ttaattgaag cagttctgaa gaacaagttt gatgtgcaga aggctttgtc aggggttctg gaacaagata gagtgcagag tttgaaggac aagaatgagg caacagtatc tacaggaaag atagcaaaag gaaaaccagt agattcccag acatcgcgaa gtgaatctga aattgtgcca aaagttgcta aaatgactgt atctggaaag aagcaaacta tgggatttga agtgcctgga gtatcttctg aagaaaatgg tcatagtttc cacacacctc aaaaaggacc gcccattgaa gatgccattg cttcttccga tgttcttgag actgcttcta aatctgctaa tccaccccac acgattcaag catcagaaga gcagagttca accccagcac cggtgaaaaa gtctggcaag ctgaggcagc aaatagatgt gaaggcggaa ctggagaagc ggcaaggagg gaagcagcta ctcaacttag tggtcattgg tcatgttgat gctgggaaaa gtactctgat gggccatatg ctttatcttc tgggtaatat aaacaaaaga actatgcata agtatgaaca ggagtctaaa aaggctggca aagcttcgtt tgcatatgca tgggtcttgg atgaaactgg cgaagaaagg gaaaggggag taaccatgga tgttggtatg acaaagtttg aaaccacaac caaagttatt acattaatgg atgctccagg ccataaggac ttcattccaa atatgattac aggagcagcc caggcggatg tagctgtttt agttgtagat gccagcaggg gagagtttga agctggattt gagactggag gacaaacacg agagcatgga ctcttggtcc gttctctggg agtgacgcag cttgcagttg cagttaataa aatggatcag gttaattggc aacaagaaag gtttcaagag attactggaa aacttgggca ctttcttaag caagcaggtt ttaaggagag tgatgtaggt tttattccta caagtggtct cagtggtgaa aatctaatca caagatctca gtcaagtgaa ctcacaaaat ggtataaagg actatgttta ttagaacaaa ttgattcctt taagcctccc cagcgatcta ttgacaaacc ttttagatta tgtgtgtccg atgttttcaa agatcaagga tctggatttt gcataactgg taaaatagaa gctggttata tccaaactgg tgaccgacta ctggcaatgc ctcctaatga aacttgtacc gtgaaaggaa tcactctgca tgatgaacct gtcgactggg cggcagcagg cgatcatgtt agtcttactt tggttgggat ggatatcatc aaaatcaatg ttggctgcat attttgtggc cccaaagtac ccattaaagc ttgcactcgt ttcagagccc gaatcctcat ctttaatatt gaaattccta tcactaaagg atttcctgtg ctgttacact accaaactgt cagtgaaccc gccgttatta aacgattgat tagtgtctta aacaaaagca cgggtgaagt cacaaagaaa aagcctaagt ttttgactaa aggccagaat gcattggtag agctacagac acaaagacca atagctcttg agctatataa agactttaaa gagctgggga ggttcatgct acgttacggt ggttctacaa tagctgctgg tgttgtcact gagataaaag Protein function: Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway (PubMed:21448132). In the presence of ABCE1 and PELO, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes (PubMed:21448132). Together with PELO and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs, this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway (PubMed:21448132). [The UniProt Consortium]