HAS2 (Vector pUC, Accession No. BC109071)

Length: 1659 Sequence: ATGCATTGTG AGAGGTTTCT ATGTATCCTG AGAATAATTG GAACCACACT CTTTGGAGTC TCTCTCCTCC TTGGAATCAC AGCTGCTTAT ATTGTTGGCT ACCAGTTTAT CCAAACGGAT AATTACTATT TCTCTTTTGG ACTGTATGGT GCCTTTTTGG CATCACACCT CATCATCCAA AGCCTGTTTG CCTTTTTGGA GCACCGAAAA ATGAAAAAAT CCCTAGAAAC CCCCATAAAG TTGAACAAAA CAGTTGCCCT TTGCATCGCT GCCTATCAAG AAGATCCAGA CTACTTAAGG AAATGTTTGC AATCTGTGAA AAGGCTAACC TACCCTGGGA TTAAAGTTGT CATGGTCATA GATGGGAACT CAGAAGATGA CCTTTACATG ATGGACATCT TCAGTGAAGT CATGGGCAGA GACAAATCAG CCACTTATAT CTGGAAGAAC AACTTCCACG AAAAGGGTCC CGGTGAGACA GATGAGTCAC ATAAAGAAAG CTCGCAACAC GTAACGCAAT TGGTCTTGTC CAACAAAAGT ATCTGCATCA TGCAAAAATG GGGTGGAAAA AGAGAAGTCA TGTACACAGC CTTCAGAGCA CTGGGACGAA GTGTGGATTA TGTACAGGTT TGTGATTCAG ACACTATGCT TGACCCAGCC TCATCTGTGG AGATGGTAAA AGTTTTAGAA GAAGATCCCA TGGTTGGAGG TGTTGGGGGA GATGTCCAGA TTTTAAACAA GTACGATTCC TGGATCTCAT TCCTCAGCAG TGTAAGATAT TGGATGGCTT TTAATATAGA AAGGGCCTGT CAGTCTTATT TTGGGTGTGT TCAGTGCATT AGTGGACCTC TGGGAATGTA CAGAAACTCC TTGTTGCATG AGTTTGTGGA AGATTGGTAC AATCAAGAAT TTATGGGCAA CCAATGTAGC TTTGGTGATG ACAGGCATCT CACGAACCGG GTGCTGAGCC TGGGCTATGC AACAAAATAC ACAGCTCGAT CTAAGTGCCT TACTGAAACA CCTATAGAAT ATCTCAGATG GCTAAACCAG CAGACCCGTT GGAGCAAGTC CTACTTCCGA GAATGGCTGT ACAATGCAAT GTGGTTTCAC AAACATCACT TGTGGATGAC CTACGAAGCG ATTATCACTG GATTCTTTCC TTTCTTTCTC ATTGCCACAG TAATCCAGCT CTTCTACCGG GGTAAAATTT GGAACATTCT CCTCTTCTTG TTAACTGTCC AGCTAGTAGG TCTCATAAAA TCATCTTTTG CCAGCTGCCT TAGAGGAAAT ATCGTCATGG TCTTCATGTC TCTCTACTCA GTGTTATACA TGTCGAGTTT ACTTCCCGCC AAGATGTTTG CAATTGCAAC AATAAACAAA GCTGGGTGGG GCACATCAGG AAGGAAAACC ATTGTTGTTA ATTTCATAGG ACTCATTCCA GTATCAGTTT GGTTTACAAT CCTCCTGGGT GGTGTGATTT TCACCATTTA TAAGGAGTCT AAAAGGCCAT TTTCAGAATC CAAACAGACA GTTCTAATTG TTGGAACGTT GCTCTATGCA TGCTATTGGG TCATGCTTTT GACGCTGTAT GTAGTTCTCA TCAATAAGTG TGGCAGGCGG AAGAAGGGAC AACAATATGA CATGGTGCTT Protein function: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix. [The UniProt Consortium]