GRHL3 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1668 Sequence: atgagagtca atggagatga tgacagtgtt gcggccttga gcttcctcta tgattactac atgggtccca aggagaagcg gatattgtcc tccagcactg ggggcaggaa tgaccaagga aagaggtact accatggcat ggaatatgag acggacctca ctccccttga aagccccaca cacctcatga aattcctgac agagaacgtg tctggaaccc cagagtaccc agatttgctc aagaagaata acctgatgag cttggagggg gccttgccca cccctggcaa ggcagctccc ctccctgcag gccccagcaa gctggaggcc ggctctgtgg acagctacct gttacccacc actgatatgt atgataatgg ctccctcaac tccttgtttg agagcattca tggggtgccg cccacacagc gctggcagcc agacagcacc ttcaaagatg acccacagga gtcgatgctc ttcccagata tcctgaaaac ctccccggaa cccccatgtc cagaggacta ccccagcctc aaaagtgact ttgaatacac cctgggctcc cccaaagcca tccacatcaa gtcaggcgag tcacccatgg cctacctcaa caaaggccag ttctaccccg tcaccctgcg gaccccagca ggtggcaaag gccttgcctt gtcctccaac aaagtcaaga gtgtggtgat ggttgtcttc gacaatgaga aggtcccagt agagcagctg cgcttctgga agcactggca ttcccggcaa cccactgcca agcagcgggt cattgacgtg gctgactgca aagaaaactt caacactgtg gagcacattg aggaggtggc ctataatgca ctgtcctttg tgtggaacgt gaatgaagag gccaaggtgt tcatcggcgt aaactgtctg agcacagact tttcctcaca aaagggggtg aagggtgtcc ccctgaacct gcagattgac acctatgact gtggcttggg cactgagcgc ctggtacacc gtgctgtctg ccagatcaag atcttctgtg acaagggagc tgagaggaag atgcgcgatg acgagcggaa gcagttccgg aggaaggtca agtgccctga ctccagcaac agtggcgtca agggctgcct gctgtcgggc ttcaggggca atgagacgac ctaccttcgg ccagagactg acctggagac gccacccgtg ctgttcatcc ccaatgtgca cttctccagc ctgcagcgct ctggaggggc agccccctcg gcaggaccca gcagctccaa caggctgcct ctgaagcgta cctgctcgcc cttcactgag gagtttgagc ctctgccctc caagcaggcc aaggaaggcg accttcagag agttctgctg tatgtgcgga gggagactga ggaggtgttt gacgcgctca tgttgaagac cccagacctg aaggggctga ggaatgcgat ctctgagaag tatgggttcc ctgaagagaa catttacaaa gtctacaaga aatgcaagcg aggaatctta gtcaacatgg acaacaacat cattcagcat tacagcaacc acgtcgcctt cctgctggac atgggggagc tggacggcaa aattcagatc atccttaagg Protein function: Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (PubMed:21081122, PubMed:25347468). xhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair. Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair but is essential to form the epidermal barrier with TGM3 as critical direct target gene among others. Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury. Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurulation. Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure. Also required for proper development of the oral periderm (PubMed:24360809). No genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity (PubMed:21081122). [The UniProt Consortium]