GPR4 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 1089 Sequence: atgggcaacc acacgtggga gggctgccac gtggactcgc gcgtggacca cctctttccg ccatccctct acatctttgt catcggcgtg gggctgccca ccaactgcct ggctctgtgg gcggcctacc gccaggtgca acagcgcaac gagctgggcg tctacctgat gaacctcagc atcgccgacc tgctgtacat ctgcacgctg ccgctgtggg tggactactt cctgcaccac gacaactgga tccacggccc cgggtcctgc aagctctttg ggttcatctt ctacaccaat atctacatca gcatcgcctt cctgtgctgc atctcggtgg accgctacct ggctgtggcc cacccactcc gcttcgcccg cctgcgccgc gtcaagaccg ccgtggccgt gagctccgtg gtctgggcca cggagctggg cgccaactcg gcgcccctgt tccatgacga gctcttccga gaccgctaca accacacctt ctgctttgag aagttcccca tggaaggctg ggtggcctgg atgaacctct atcgggtgtt cgtgggcttc ctcttcccgt gggcgctcat gctgctgtcg taccggggca tcctgcgggc cgtgcggggc agcgtgtcca ccgagcgcca ggagaaggcc aagatcaagc ggctggccct cagcctcatc gccatcgtgc tggtctgctt tgcgccctat cacgtgctct tgctgtcccg cagcgccatc tacctgggcc gcccctggga ctgcggcttc gaggagcgcg tcttttctgc ataccacagc tcactggctt tcaccagcct caactgtgtg gcggacccca tcctctactg cctggtcaac gagggcgccc gcagcgatgt ggccaaggcc ctgcacaacc tgctccgctt tctggccagc gacaagcccc aggagatggc caatgcctcg ctcaccctgg agaccccact cacctccaag aggaacagca cagccaaagc catgactggc agctgggcgg ccactccgcc ctcccagggg gaccaggtgc agctgaagat gctgccgcca Protein function: Proton-sensing G-protein coupled receptor couples to multiple intracellular signaling pathways, including GNAS/cAMP, GNAQ/phospholipase C (PLC), and GNA12/GNA13/Rho pathways (PubMed:12955148, PubMed:17462861, PubMed:22110680, PubMed:20211729). Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells through the GNA12/GNA13/Rho GTPase signaling pathway (PubMed:32058960). In the brain may mediate central respiratory sensitivity to CO(2)H(+). [The UniProt Consortium]