GPR18 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 996 Sequence: atgatcaccc tgaacaatca agatcaacct gtccctttta acagctcaca tccagatgaa tacaaaattg cagcccttgt cttctatagc tgtatcttca taattggatt atttgttaac atcactgcat tatgggtttt cagttgtacc accaagaaga gaaccacggt aaccatctat atgatgaatg tggcattagt ggacttgata tttataatga ctttaccctt tcgaatgttt tattatgcaa aagatgaatg gccatttgga gagtacttct gccagattct tggagctctc acagtgtttt acccaagcat tgctttatgg cttcttgcct ttattagtgc tgacagatac atggccattg tacagccgaa gtacgccaaa gaacttaaaa acacgtgcaa agccgtgctg gcgtgtgtgg gagtctggat aatgaccctg accacgacca cccctctgct actgctctat aaagacccag ataaagactc cactcccgcc acctgcctca agatttctga catcatctat ctaaaagctg tgaacgtgct gaacctcact cgactgacat tttttttctt gattcctttg ttcatcatga ttgggtgcta cttggtcatt attcataatc tccttcacgg caggacgtct aagctgaaac ccaaagtcaa ggagaagtcc ataaggatca tcatcacgct gctggtgcag gtgctcgtct gctttatgcc cttccacatc tgtttcgctt tcctgatgct gggaacgggg gagaacagtt acaatccctg gggagccttt accaccttcc tcatgaacct cagcacgtgt ctggatgtga ttctctacta catcgtttca aaacaatttc aggctcgagt cattagtgtc atgctatacc gtaattacct tcgaagcatg cgcagaaaaa gtttccgatc tggtagtcta cggtcactaa gcaatataaa cagtgaaatg Protein function: Receptor for endocannabinoid N-arachidonyl glycine (NAGly) (PubMed:16844083, PubMed:24762058, PubMed:27572937). However, conflicting results about the role of NAGly as an agonist are reported (PubMed:27018161). Can also be activated by plant-derived and synthetic cannabinoid agonists (PubMed:24762058). The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (PubMed:16844083). May contribute to regulation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs)in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant. Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure. Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (PubMed:27572937). [The UniProt Consortium]