GEMIN8 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 729 Sequence: atggcagcgg taaaggcatc aacatcgaaa gctaccaggc cttggtattc tcatccggta tatgcaagat actggcaaca ttatcatcaa gcaatggctt ggatgcaaag ccatcacaat gcctacagga aggccgtgga atcctgtttc aatcttccat ggtacttacc ttctgcgctt cttccccaaa gctcttacga taatgaggct gcgtatcctc agtccttcta tgaccatcat gtggcctggc aggactaccc ctgcagttct tcacatttca gaagatctgg gcagcatcca cgttacagca gtaggatcca ggcatccaca aaagaagacc aagctttgtc caaagaggaa gagatggaga ctgagtcaga tgcagaggta gaatgtgacc tgagcaatat ggaaatcact gaagagctcc gccagtactt tgcagagacc gagaggcata gagaagaacg acggcggcag cagcagctgg atgcagagcg cctggacagc tatgtgaacg ctgaccacga cctgtactgc aacacccgcc ggtcggtaga agccccaact gagaggcctg gtgagcggcg ccaggccgag atgaagcgtt tgtacgggga cagtgctgcc aagatccaag ccatggaggc cgcggtgcag ctgagctttg acaagcactg tgaccgaaag cagcccaagt actggccggt catccccctg Protein function: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. [The UniProt Consortium]