GAR1 (Vector pUC, Accession No. BC003413)

Length: 654 Sequence: atgtcttttc gaggcggagg tcgtggaggc tttaatcgag gtggtggagg tggcggcttc aaccgaggcg gcagcagcaa ccacttccga ggtggaggcg gcggtggagg cggcggcaat ttcagaggcg gcggcagggg aggatttgga cgagggggtg gccgcggagg ctttaacaaa ggccaagacc aaggacctcc agaacgtgta gtcttattag gagagttcct gcatccctgt gaagatgaca tagtttgtaa atgtaccaca gatgaaaata aggtgcctta tttcaatgct cctgtttact tagaaaacaa agaacaaatt ggaaaagtgg atgaaatatt tggacaactc agagattttt atttttcagt taagttgtca gaaaacatga aggcttcatc ctttaaaaaa ctacagaagt tttatataga cccatataag ctgctgccac tgcagaggtt tttacctcga cctccaggtg agaaaggacc tccaagaggt ggtggcaggg gaggccgagg aggaggaaga ggaggaggtg gcagaggtgg tggcagaggt ggtggtttta gaggtggaag aggaggtgga ggtgggggct tcagaggagg aagaggtggt ggtttcagag ggagaggaca Protein function: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. [The UniProt Consortium]