GAPVD1 (Vector pUC, Accession No. BC114937)

Length: 4383 Sequence: ATGGTGAAAC TAGATATTCA TACTCTGGCT CATCACCTCA AGCAGGAACG CTTATATGTA AACTCTGAGA AACAGCTCAT TCAGAGGCTC AATGCAGATG TACTTAAGAC AGCTGAAAAG TTGTATCGTA CAGCATGGAT TGCGAAGCAA CAGAGAATCA ATTTGGATCG GCTTATCATA ACCAGTGCTG AAGCTTCCCC TGCTGAATGT TGCCAACATG CCAAAATTTT GGAAGATACA CAATTTGTTG ATGGGTATAA GCAATTGGGA TTTCAGGAGA CTGCTTATGG AGAATTCTTG AGTCGATTGA GGGAAAATCC TCGTCTTATT GCCTCCTCTT TGGTTGCTGG AGAGAAACTT AATCAGGAGA ACACACAAAG TGTTATTTAC ACAGTTTTTA CCTCCCTGTA TGGCAATTGC ATCATGCAAG AAGATGAAAG CTACCTCCTT CAGGTTTTGC GATACTTGAT TGAATTTGAA CTTAAAGAAA GTGACAACCC TAGGCGACTT TTGAGGAGAG GAACTTGTGC CTTCAGCATC TTATTTAAAC TTTTTTCTGA AGGACTGTTT TCTGCCAAAC TTTTCCTCAC AGCCACTTTA CATGAGCCAA TTATGCAACT GCTTGTTGAA GATGAAGATC ACCTGGAAAC AGATCCAAAC AAGCTAATTG AGAGGTTCTC TCCATCTCAG CAGGAAAAAC TCTTTGGAGA GAAGGGCTCA GATAGATTCA GGCAAAAAGT TCAAGAAATG GTGGAGTCCA ATGAAGCAAA GCTAGTGGCT TTGGTGAACA AATTTATTGG TTATCTCAAA CAGAACACAT ATTGTTTTCC ACATAGTTTA AGGTGGATCG TGTCTCAGAT GTACAAAACC CTCTCCTGTG TAGATAGGCT GGAAGTTGGG GAGGTCAGGG CAATGTGTAC TGATCTCCTG TTGGCCTGCT TCATTTGTCC TGCAGTTGTC AATCCAGAAC AATATGGAAT AATTTCCGAT GCTCCTATTA ATGAAGTAGC ACGATTTAAT CTGATGCAGG TAGGCCGCCT TTTGCAGCAG TTAGCAATGA CTGGCTCTGA AGAGGGAGAT CCCCGAACAA AGAGCAGCCT TGGAAAGTTT GACAAAAGCT GTGTTGCCGC TTTCCTTGAT GTTGTGATTG GGGGCCGTGC AGTGGAGACC CCTCCATTGT CTTCCGTCAA TCTTCTGGAA GGATTGAGCA GAACTGTGGT TTATATAACC TACAGTCAGC TTATTACTCT GGTGAATTTT ATGAAGAGTG TGATGTCTGG AGATCAACTG AGAGAAGATA GAATGGCTCT TGACAATTTA TTGGCAAACC TACCCCCGGC CAAGCCAGGA AAAAGTAGCA GTTTAGAAAT GACTCCCTAC AATACACCTC AGCTATCTCC AGCAACCACT CCAGCAAATA AAAAGAATCG ATTACCTATA GCAACTCGGA GCAGAAGCCG CACCAATATG CTAATGGACC TACATATGGA CCATGAAGGA TCATCTCAAG AAACCATCCA GGAGGTGCAA CCAGAAGAGG TGTTGGTCAT TTCCTTAGGT ACAGGTCCCC AGCTTACTCC AGGGATGATG TCAGAAAATG AGGTCCTAAA CATGCAGCTT TCGGATGGAG GACAAGGAGA TGTCCCTGTT GATGAAAACA AACTCCATGG TAAACCTGAT AAAACCTTGC GCTTTTCCCT CTGCAGTGAT AATCTGGAAG GAATATCTGA AGGTCCTTCA AATCGCTCCA ATTCAGTGTC CTCCCTAGAC CTAGAAGGAG AGTCTGTGTC AGAACTTGGA GCAGGACCTT CTGGCAGTAA TGGAGTTGAA GCTCTACAGC TGTTAGAACA TGAGCAAGCT ACAACACAGG ATAACCTTGA TGATAAGCTA AGGAAGTTTG AAATTCGTGA CATGATGGGA TTAACAGATG ATAGGGACAT ATCAGAAACA GTGAGTGAGA CCTGGAGTAC AGACGTCTTG GGAAGTGACT TTGACCCTAA TATTGATGAA GATCGCTTGC AAGAAATTGC AGGTGCTGCA GCAGAGAACA TGTTAGGCAG TTTGCTGTGC CTCCCAGGTT CAGGGTCAGT GCTTCTTGAC CCCTGCACTG GTTCTACCAT ATCAGAGACA ACAAGTGAAG CTTGGAGTGT AGAGGTATTG CCAAGTGACT CAGAGGCCCC AGACCTAAAG CAGGAGGAGC GTCTGCAAGA ACTGGAGAGC TGTTCTGGAC TGGGTAGCAC ATCTGATGAT ACGGATGTCA GGGAGGTCAG TTCCCGCCCC AGCACACCAG GCCTCAGTGT TGTGTCCGGC ATAAGTGCAA CCTCTGAGGA TATTCCCAAT AAGATTGAAG ACCTGAGATC TGAGTGCAGC TCTGATTTTG GGGGTAAAGA TTCTGTCACT AGTCCAGACA TGGATGAAAT AACTCACGGT GCCCACCAGC TGACCTCTCC TCCTTCTCAG TCAGAGTCTC TGCTGGCCAT GTTTGATCCA CTGTCTTCAC ATGAAGGGGC TTCTGCTGTG GTAAGGCCAA AGGTTCACTA TGCTAGGCCA TCGCATCCAC CACCAGATCC CCCAATCCTG GAAGGAGCTG TGGGAGGAAA TGAGGCCAGG TTGCCAAACT TTGGTTCCCA TGTTTTAACT CCAGCTGAAA TGGAGGCATT CAAGCAAAGG CATTCTTACC CTGAGAGACT AGTTCGAAGC AGGAGCTCTG ATATAGTATC TTCTGTCCGG AGACCCATGA GTGACCCCAG CTGGAACCGG CGTCCAGGAA ATGAAGAGCG AGAACTCCCT CCAGCTGCAG CCATTGGTGC TACTTCTTTG GTGGCTGCAC CTCATTCATC ATCTTCATCC CCGAGTAAGG ACTCCTCAAG AGGAGAGACT GAAGAACGCA AAGATAGCGA TGATGAGAAA TCAGACAGGA ACAGACCTTG GTGGAGAAAA CGTTTTGTTT CAGCCATGCC TAAAGCTCCT ATACCATTTA GAAAGAAAGA AAAACAAGAA AAAGACAAAG ATGATCTGGG GCCTGACAGA TTCTCAACAC TCACAGATGA TCCCAGCCCT AGACTCAGTG CACAAGCTCA GGTGGCTGAG GATATTCTGG ACAAATACAG GAATGCCATT AAACGGACCA GCCCCAGTGA TGGAGCAATG GCAAACTATG AAAGTACAGA GGTTATGGGT GATGGTGAAA GTGCACATGA TTCTCCCCGT GACGAAGCAC TGCAGAACAT CTCGGCTGAT GATCTCCCAG ACTCTGCAAG CCAAGCAGCC CACCCGCAGG ATTCAGCTTT CTCTTACAGA GATGCAAAAA AGAAACTGAG GCTTGCTCTT TGCTCTGCGG ACTCTGTTGC CTTCCCAGTG CTGACCCATT CAACAAGGAA TGGTTTACCA GACCACACAG ACCCAGAAGA CAATGAAATT GTATGCTTCT TAAAAGTTCA AATAGCTGAA GCAATTAATT TACAAGATAA GAATCTAATG GCTCAACTTC AAGAAACAAT GCGCTGTGTG TGCCGTTTTG ATAATAGGAC TTGTAGGAAA CTGCTGGCTT CGATTGCTGA GGACTACAGA AAAAGAGCCC CATATATTGC TTATCTCACT CGTTGTCGAC AAGGACTACA GACCACACAG GCTCACCTGG AAAGGCTATT GCAAAGAGTT TTGCGGGACA AAGAAGTGGC CAATCGATAC TTTACCACTG TCTGTGTGAG ATTACTGCTT GAGAGCAAAG AAAAGAAGAT CAGGGAATTC ATTCAAGACT TTCAGAAACT CACCGCAGCT GACGATAAAA CTGCTCAGGT AGAAGATTTT CTGCAGTTTC TTTATGGTGC AATGGCCCAG GATGTCATAT GGCAAAACGC GAGTGAAGAA CAGCTTCAAG ATGCACAGCT GGCCATTGAG CGAAGCGTGA TGAACCGGAT TTTCAAGCTC GCCTTCTACC CTAATCAAGA TGGGGACATA CTTCGCGACC AGGTTCTTCA TGAACATATC CAGAGATTGT CTAAAGTAGT GACTGCAAAT CACAGAGCTC TTCAGATACC AGAGGTTTAT CTTCGAGAAG CACCATGGCC ATCTGCACAA TCAGAAATCA GGACAATAAG TGCTTATAAA ACCCCCCGGG ACAAAGTGCA GTGCATCCTG AGAATGTGCT CTACGATTAT GAACCTCCTG AGCCTGGCCA ATGAGGACTC TGTCCCTGGA GCGGATGACT TTGTTCCTGT GTTGGTGTTT GTGTTGATAA AGGCAAATCC ACCCTGTTTG CTGTCTACTG TGCAGTATAT CAGTAGCTTT TATGCTAGCT GTCTGTCTGG AGAGGAGTCC TATTGGTGGA TGCAGTTCAC AGCAGCAGTA GAATTCATTA AAACCATCGA TGACCGAAAG Protein function: Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras. [The UniProt Consortium]