FUT2 (Vector pENTR223.1, Accession No. BC001899)

Length: 462 Sequence: atgctggtcg ttcagatgcc tttctccttt cccatggccc acttcatcct ctttgtcttt acggtttcca ctatatttca cgttcagcag cggctagcga agattcaagc catgtgggag ttaccggtgc agataccagt gctagcctca acatcaaagg cactgggacc cagccagctc agggggatgt ggacgatcaa tgcgataggc cgcctgggga accagatggg cgagtacgcc acactgtatg ccctggccaa gatgaacggg cggcccgcct tcatcccggc ccagatgcac agcaccctgg cccccatctt cagaatcacc ctgccggtgc tgcacagcgc cacggccagc aggatcccct ggcagaacta ccacctgaac gactggatgg aggaggaata ccgccacatc ccgggggagt acgtccgctt caccggctac ccctgctcct Protein function: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N- linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation (PubMed:7876235, PubMed:8018146, PubMed:12692541). Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs. Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition (PubMed:22068912, PubMed:21625510, PubMed:24733310). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235). [The UniProt Consortium]