FRMD8 (Vector pUC, Accession No. BC044658)

Length: 1395 Sequence: atggacggga cagaaggcag tgccgggcag cccggccccg ctgagcgatc ccaccgaagc agcgtgtcct ccgtgggagc ccgagcggct gacgtgctgg tatacctagc ggatgacacg gtggtgcccc tggctgtgga gaacctgccc tcgctcagtg cccatgagct gcaccgcgct gtccgcgagg tcctgcagct tccagacatc gccctggatg tcttcgcgct ctggctggtc tcccctctgc tggaggtgca gctgaaaccc aagcaccagc cctacaagct gggacgccag tggccggagc tgctgctgcg cttcaccagt gccccagatg atgacgtggc catggatgag cctttcctgc agttccgaag gaacgtgttc ttcccaaagc ggcgggagct ccagatccat gacgaggagg tcctgcggct gctctatgag gaggccaagg gcaacgtgct ggctgcacgg tacccgtgcg acgtggagga ctgcgaggct ctgggcgccc tggtgtgccg cgtgcagctt gggccctacc agcccggccg gccggcagcc tgcgacctga gggagaagct ggactccttc ctccctgccc acctctgtaa gcggggccag agtctctttg ctgccctccg gggccgtggg gccagggccg ggccgggcga gcagggcctg ctgaacgcct accgccaggt gcaggaggtc agcagcgacg gcgggtgcga ggccgccctg ggcacccact accgcgccta tctcctcaag tgccacgagc tgccgtttta tgggtgtgcc ttcttccacg gtgaggttga caagccggcc caaggctttt tgcaccgggg tgggcgcaag ccagtttctg tggccatcag tctggaaggc gtgcacgtca tcgatagcag agagaagcat gtcctgctgg gcctgcgctt ccaggagctg tcgtgggacc acacctcccc cgaggaggag gagcccatct tgtggctgga gttcgacggg gacagcgagg gcacacctgt caacaagctc ctcaagatct actccaagca ggccgaactg atgagcagtc tcattgagta ctgcatcgaa ctgagccagg cggcggagcc cgcaggcccc caggacagtg cgactggctc gccctcggac cccagctcct cactggctcc tgttcagcgc cccaagctgc ggaggcaggg cagtgtggtg tccagccgga tccagcatct ctccaccatc gactacgtgg aggacggcaa ggggatcagg cgagtgaagc cgaagcgcac cacatccttc ttcagccggc agctgtcctt gggccagggg agctacaccg tggtgcagcc cggcgacagc ctggagcagg Protein function: Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019). [The UniProt Consortium]