FN3K (Vector pUC, Accession No. BC042680)

Length: 930 Sequence: atggagcagc tgctgcgcgc cgagctgcgc accgcgaccc tgcgggcctt cggcggcccc ggcgccggct gcatcagcga gggccgagcc tacgacacgg acgcaggccc agtgttcgtc aaagtcaacc gcaggacgca ggcccggcag atgtttgagg gggaggtggc cagcctggag gccctccgga gcacgggcct ggtgcgggtg ccgaggccca tgaaggtcat cgacctgccg ggaggtgggg ccgcctttgt gatggagcat ttgaagatga agagcttgag cagtcaagca tcaaaacttg gagagcagat ggcagatttg catctttaca accagaagct cagggagaag ttgaaggagg aggagaacac agtgggccga agaggtgagg gtgctgagcc tcagtatgtg gacaagttcg gcttccacac ggtgacgtgc tgcggcttca tcccgcaggt gaatgagtgg caggatgact ggccgacctt tttcgcccgg caccggctcc aggcgcagct ggacctcatt gagaaggact atgctgaccg agaggcacga gaactctggt cccggctaca ggtgaagatc ccggatctgt tttgtggcct agagattgtc cccgcgttgc tccacgggga tctctggtcg ggaaacgtgg ctgaggacga cgtggggccc attatttacg acccggcttc cttctatggc cattccgagt ttgaactggc aatcgccttg atgtttgggg ggttccccag atccttcttc accgcctacc accggaagat ccccaaggct ccgggcttcg accagcggct gctgctctac cagctgttta actacctgaa ccactggaac cacttcgggc gggagtacag gagcccttcg ttgggcacca tgcgaaggct Protein function: Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate (PubMed:11016445, PubMed:11522682, PubMed:11975663). Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed:11522682, PubMed:11975663). Involved in intracellular deglycation in erythrocytes (PubMed:11975663). Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function. Also able to phosphorylate psicosamines and ribulosamines (PubMed:14633848). [The UniProt Consortium]