FMO5 (Vector pENTR223.1, Accession No. BC035687)

Length: 858 Sequence: atgactaaga aaagaattgc tgtgattggg ggaggagtga gcgggctctc ttccatcaag tgctgcgtag aagaaggctt ggaacctgtc tgctttgaaa ggactgatga catcggaggg ctctggaggt tccaggaaaa tcctgaagaa ggaagggcca gtatttacaa atcagtgatc atcaatactt ctaaagagat gatgtgcttc agtgactatc caatcccaga tcattatccc aacttcatgc ataatgccca ggtcctggag tatttcagga tgtatgccaa agaatttgac cttctaaagt atattcgatt taagaccact gtgtgcagtg tgaagaagca gcctgatttt gccacttcag gccaatggga agtggtcact gaatctgaag ggaaaaagga gatgaatgtc tttgatggag tcatggtttg cactggccat cacaccaatg ctcatctacc tctggaaagc ttccctggaa ttgagaagtt caaagggcag tacttccaca gtcgagacta taagaaccca gagggattca ctggaaagag agtcattata attggcattg ggaattctgg aggggatctg gctgtagaga ttagccaaac agccaagcag gttttcctca gcaccaggag aggggcttgg atcctgaatc gtgtagggga ctacggatat cctgctgatg tgttgttctc ttctcgactt acacatttta tatggaagat ctgtggccaa tcattagcaa acaaatattt ggaaaaaaag ataaaccaaa ggtttgacca tgaaatgttt ggcctgaagc ctaaacacag gtctaaagac attgccctca Protein function: Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon- carbon bond adjacent to a carbonyl, which converts ketones to esters (PubMed:28783300, PubMed:26771671, PubMed:20947616). Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive (PubMed:26771671, PubMed:7872795). In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms (Probable) (PubMed:7872795). Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline (PubMed:28783300). Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity (PubMed:26771671). Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects. [The UniProt Consortium]