FLVCR1 (Vector pUC, Accession No. BC048312)

Length: 1668 Sequence: atggcgcggc cagacgatga ggagggggcg gcggtggcgc ccggacaccc gctcgcgaaa ggatacctcc cgttgccgag gggcgcgccc gttgggaagg agagcgtgga gctgcagaac gggcccaaag cgggcacctt cccggtgaat gggccccccc gggacagcct cgctgccgcc tcgggagttc tgggcgggcc tcagactcca ctggccccag aagaggagac ccaggcccgg ctgctgcctg cgggcgcggg agctgagacc ccgggggccg agagcagccc gctgcccctt acggcgctct ccccgcggcg cttcgtggtg ctcctgatct tcagcctgta ctcgctggtc aacgcctttc agtggatcca gtacagcatc attagcaacg tcttcgaggg cttctacggt gtcaccttgc tgcacatcga ctggctgtcc atggtgtaca tgctggccta cgtgcccctc atcttcccgg ccacctggct gctggacacc agaggcctgc ggctcaccgc cctgctgggc tccggcctca actgcctggg tgcctggatc aagtgcggca gtgtgcagca gcatctcttc tgggtcacca tgttgggcca gtgcttgtgc tcggtggccc aggtgttcat cctgggcttg ccctcccgca tcgcctcagt gtggtttggg cccaaagagg tgtccacagc ttgtgccacc gccgtgctgg gcaatcagct tggaactgca gttggctttt tgctaccacc agttttagta cccaacacac agaatgacac aaatctcctg gcttgtaata tcagcaccat gttttatgga acatcagctg ttgccacact tttatttatt ttaacagcaa ttgccttcaa agaaaaacct cggtatccac caagtcaggc tcaagcagct cttcaagaca gtccccctga agagtactcc tataagaaat caataagaaa cctgtttaaa aacattcctt ttgtccttct gttgatcact tatggtatca tgactggtgc cttttattca gtctcaacgt tattaaatca aatgatattg acatattatg agggagaaga agtcaatgct ggaaggattg ggctaacgct agtagtagct ggaatggtgg gctctattct ttgtggctta tggctggatt atactaaaac atacaaacag actactctga tagtttatat tttgtctttt attggaatgg ttatctttac tttcacattg gaccttagat acattatcat cgtgtttgtt actggagggg tgcttggctt cttcatgact ggttacctcc ctttgggttt tgaatttgct gttgaaatca cttaccctga atctgaaggt acttcatctg gtcttcttaa tgcttctgca cagatatttg gaattttgtt cacattggct caaggaaagc tcacatcaga ctatggtcct aaggcaggga acatttttct ctgtgtctgg atgtttatag gcatcatatt aacagcatta atcaagtctg atctgcgaag acacaacata aatataggaa ttacaaatgt tgatgttaaa gctataccag ctgacagtcc cacagaccaa gaaccaaaaa tggttatgtt gtccaagcag tcagaatcag Protein function: [Isoform 1]: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythtopoiesis, a process in which heme synthesis intensifies. Causes susceptibility to FeLV-C in vitro. [The UniProt Consortium]