FBXO11 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 2532 Sequence: atggttgcag aagaatcagg tcctggtgca caaaatagtc cataccaact tcgtagaaaa actcttttgc cgaaaagaac agcgtgtccc acaaagaaca gtatggaggg cgcctcaact tcaactacag aaaactttgg tcatcgtgca aaacgtgcaa gagtgtctgg aaaatcacaa gatctatcag cagcacctgc tgaacagtat cttcaggaga aactgccaga tgaagtggtt ctaaaaatct tctcttactt gctggaacag gatctttgta gagcagcttg tgtatgtaaa cgcttcagtg aacttgctaa tgatccaatt ttgtggaaac gattatatat ggaagtattt gaatatactc gccctatgat gcatcctgaa cctggaaaat tctaccagat taatccagaa gagtatgaac atccaaatcc ctggaaagag agtttccagc agttgtataa aggtgcacat gtaaagccag gatttgctga acatttctac agtaaccctg caagatataa aggaagagaa aatatgttgt attatgatac tattgaagat gcccttggtg gggtacaaga ggctcatttt gatggactta tctttgttca ttctggaata tatactgatg aatggatata tattgaatct ccaatcacca tgattggtgc agcacctggg aaagtggcag acaaagttat aattgaaaac actagagatt caaccttcgt ttttatggaa ggctctgaag atgcttatgt tggatatatg acaataaggt ttaaccctga tgacaaatct gcacaacacc acaatgcaca ccactgctta gagattacag taaattgtag ccctattatt gatcactgta tcatccgaag tacatgtaca gttggttctg cagtatgtgt tagtggtcaa ggagcatgtc ccaccatcaa gcactgtaac atcagtgact gtgaaaatgt tggactatat ataacagatc atgcacaggg aatatatgag gataatgaaa tttccaataa tgcgttagct gggatttggg ttaaaaatca tggaaaccca attattagac ggaatcatat tcatcatgga cgtgatgttg gtgtgttcac atttgatcat ggcatgggtt actttgaaag ttgcaatata cacagaaata ggatagcagg ctttgaagta aaagcctatg ctaaccctac agtggttcga tgtgaaattc accatgggca gactggagga atatatgtcc atgaaaaagg aagaggacaa ttcatagaga ataaaatcta tgcaaacaac tttgcaggtg tatggattac ctcaaatagt gacccaacaa taaggggaaa ttctatattt aatggaaatc aaggaggagt ttacatcttt ggtgatggac gaggccttat tgaaggaaat gacatttatg gcaatgcatt agcaggaatt caaattagga caaacagttg tccaattgtt cggcataaca aaattcatga tggccagcat ggtgggattt atgtgcatga aaagggacaa ggagtaatag aagagaatga agtttatagt aacactctag ctggagtctg ggtgacaact ggcagcactc cagtactgag aagaaaccgg atacacagtg gcaagcaggt tggtgtttat ttttatgaca atggacatgg agtgctagaa gacaatgata tctataatca tatgtattca ggggttcaga taaggactgg aagcaacccc aaaattagac gcaacaaaat ctggggagga cagaatggtg gaattctagt ttataattct ggtctaggct gtatagaaga caatgaaata tttgacaatg caatggctgg agtctggatt aagacagata gtaatcctac actaagaaga aataaaatcc atgatggaag agatggtggc atctgtatat ttaatggggg tcgaggtctc cttgaagaaa atgatatttt caggaatgct caagcaggtg ttctcatcag cactaatagt catccaatct taaggaaaaa cagaatattt gatggatttg ccgcaggtat tgaaattaca aatcacgcaa ctgcaacact agaaggcaat cagattttta acaaccggtt tggaggctta tttttagcat ctggtgttaa tgtgacaatg aaagataaca aaataatgaa caatcaagat gccatagaaa aggctgttag tagaggccaa tgtttatata aaatatcaag ttataccagc tatcccatgc atgatttcta cagatgtcat acttgtaaca ccacagatcg aaatgccata tgtgtgaact gcattaagaa gtgccatcag ggacatgatg tagagtttat tagacatgat aggtttttct gtgactgtgg tgctggaaca ctgtctaatc cttgtacatt agctggtgag cctacacatg atacagatac actatatgac tctgctccac ctatagaatc taatacattg cagcacaact Protein function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53. [The UniProt Consortium]