FBXL17 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 912 Sequence: atgtctgata atggcgtatg tgttttagca tttaaatgtc ctggacttct taggtataca gcctacaggt gtaaacagct ttctgacacc tctattattg cggttgcctc tcactgtcct ttacttcaga aagtgcatgt aggcaaccag gacaaactca ctgatgaagg actcaagcag ctgggctcaa aatgcagaga actcaaagat attcatttcg gccagtgtta caagatctca gatgaaggca tgatcgtcat agctaagggc tgtctgaaat tacaaaggat atacatgcag gaaaacaaat tagtgacaga tcagtcagtg aaagcatttg ctgaacactg tcctgagctt caatatgtag gcttcatggg ttgttcagtc acttctaaag gagtcattca cctaaccaag ctaagaaacc tttccagctt ggacctacgt catatcactg aactggataa tgaaaccgtg atggaaattg tcaagaggtg caaaaatctt agctctctca atctctgtct gaactggatc ataaatgaca ggtgtgtgga ggtcattgca aaggaaggac aaaacctgaa agagctatat ttggtgtcct gtaaaatcac agattatgca ctgatagcca ttgggcgata cagcatgaca atagagactg tggatgtcgg atggtgtaaa gaaatcacag accaaggagc caccctgatt gcacagagca gcaagtctct gagatatttg gggctgatga gatgtgataa agtcaacgaa gtgacggtgg aacagctggt gcagcagtac ccccacatca ccttcagcac cgtcctgcag gactgcaaga ggaccttgga gagagcctat cagatgggct ggacccccaa catgtctgcc gcctcctcct Protein function: Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC) (PubMed:30190310). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteaseome (PubMed:30190310). The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells. The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1 (PubMed:24035498, PubMed:30190310). The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction (PubMed:27234298). The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1. [The UniProt Consortium]