FAM60A (Vector pENTR223.1, Accession No. BC000024)

Length: 666 Sequence: atgtttggtt ttcacaagcc aaagatgtac cgaagtatag agggctgctg tatttgcaga gctaagtcct ccagttctcg attcactgac agtaaacgct atgaaaagga cttccagagc tgttttggat tgcatgagac tcgttcagga gacatctgca atgcctgtgt cctgcttgtg aaaagatgga agaagttgcc agcaggatca aaaaaaaact ggaatcatgt ggtagatgca agggctggac ccagtctaaa gactacattg aaaccaaaga aagtgaaaac tctatctggg aacaggataa aaagcaacca gatcagtaaa ctgcagaagg aatttaaacg tcataattct gatgctcaca gtaccacctc aagtgcctcc ccagctcaat ctccttgtta cagtaaccag tcagatgacg gctcagatac agagatggct tctggttcta acagaacacc agttttttcc tttttagatc tcacttactg gaaaagacag aagatatgtt gtgggatcat ctataaaggc cgttttgggg aagtcctcat tgacacacat ctcttcaagc cttgctgcag caataagaaa gcagctgctg agaagccaga ggagcagggg ccagagcctc tgcccatctc cactcaggag Protein function: Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway (PubMed:22865885, PubMed:22984288). Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells. Promotes the stability of SIN3A and its presence on chromatin and is essential for maintaining the potential of ES cells to proliferate rapidly, while ensuring a short G1-phase of the cell cycle, thereby preventing premature lineage priming. [The UniProt Consortium]