FAM49B (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 975 Sequence: atggggaatc ttcttaaagt tttgacatgc acagaccttg agcaggggcc aaattttttc cttgattttg aaaatgccca gcctacagag tctgagaagg aaatttataa tcaggtgaat gtagtattaa aagatgcaga aggcatcttg gaggacttgc agtcatacag aggagctggc cacgaaatac gagaggcaat ccagcatcca gcagatgaga agttgcaaga gaaggcatgg ggtgcagttg ttccactagt aggcaaatta aagaaatttt acgaattttc tcagaggtta gaagcagcat taagaggtct tctgggagcc ttaacaagta ccccatattc tcccacccag catctagagc gagagcaggc tcttgctaaa cagtttgcag aaattcttca tttcacactc cggtttgatg aactcaagat gacaaatcct gccatacaga atgatttcag ctattataga agaacattga gtcgtatgag gattaacaat gtaccggcag aaggagaaaa tgaagtaaat aatgaattgg caaatcgaat gtctttgttt tatgctgagg caactccaat gctgaaaacc ttgagtgatg ccacaacaaa atttgtatca gagaataaaa atttaccaat agaaaatacc acagattgtt taagcacaat ggctagtgta tgcagagtca tgctggaaac accggaatac agaagcagat ttacaaatga agagacagtg tcattctgct tgagggtaat ggtgggtgtc ataatactct atgaccacgt acatccagtg ggagcatttg ctaaaacttc caaaattgat atgaaaggtt gtatcaaagt tcttaaggac caacctccta atagtgtgga aggtcttcta aatgctctca ggtacacaac aaaacatttg aatgatgaga ctacctccaa gcaaattaaa tccatgctgc Protein function: Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling (PubMed:31285585, PubMed:30250061). Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE- induced actin polymerization (PubMed:30250061). Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE- mediated bacterial entry (PubMed:31285585). Restricts also infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes. Involved in the regulation of mitochondrial dynamics and oxidative stress (PubMed:29059164). [The UniProt Consortium]