FAM122A (Vector pUC, Accession No. BC013062)

Length: 864 Sequence: atggctcagg agaagatgga gctagacctg gagctgcctc cgggtacggg cgggagcccg gcggagggcg gtggcagcgg cggcggcggg ggcctcagga ggtctaacag cgcccccctg atccacggcc tcagtgacac ttcgccggtg ttccaggccg aggcgccgag cgccaggcgg aacagcacaa cgttcccgag ccgccacggc ctgctgctgc cggcctcccc tgtccgcatg cacagcagcc gcttgcacca gatcaaacaa gaagagggca tggacttgat caaccgagag acggtccacg aacgggaggt gcagaccgca atgcagataa gccactcctg ggaggaaagt ttcagcctga gtgacaacga cgtggagaaa tccgcctccc ccaagcgcat cgatttcatt cctgtgtcac cagcaccgtc acccactcgg ggaattggga agcagtgttt ttcgccatcc ttgcaaagtt ttgtaagtag caacggattg cctccaagcc ctattcccag cccaacgacc cgatttacca cccggagaag ccagagcccc atcaattgca ttagaccaag tgttcttgga ccattgaaaa gaaaatgtga aatggaaact gaatatcagc caaagagatt tttccagggc atcaccaaca tgctttcttc tgacgttgca cagctgtcag atcctggtgt gtgtgtatct tcggataccc ttgatggaaa cagcagcagt gccggatctt cttgtaactc accagcgaaa gtcagcacta ccaccgactc tcctgtgtca cctgcccaag cggcttctcc atttattcca ctagatgaac tttcgtctaa Protein function: Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (PubMed:27588481, PubMed:33108758). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (PubMed:27588481). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin- mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (PubMed:33108758). [The UniProt Consortium]