FAM105B (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 645 Sequence: atgagccagg ctgtggggct gccgccctgg ctgcaggacc cggagctcat gctgttacca gaaaaactca taagcaaata caactggatc aagcaatgga aacttggact gaaatttgat gggaagaatg aggacctggt tgataaaatt aaagagtccc ttactctgct gaggaagaag tgggcaggct tggctgaaat gagaactgct gaagcaagac agatagcttg tgatgaacta ttcacaaatg aggcggagga atatagcctc tatgaagctg taaaatttct aatgctaaac agagccattg aactatataa tgataaagag aaaggaaagg aagtaccatt tttctctgtg cttctgtttg ctcgggacac atcaaatgac ccaggacagc ttctgaggaa ccacctcaac caggtgggac acactggtgg tcttgaacag gttgaaatgt tccttcttgc ctatgctgtg cgccacacca tccaggtgta ccggctctcc aagtacaaca cggaagaatt catcacagtc taccccaccg acccacccaa ggactggcca gtggtaacgc tcattgctga ggacgatcgg cactataaca tccccgtcag agtgtgtgag gagaccagtc Protein function: Deubiquitinase that specifically removes linear ('Met-1'- linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed:26997266, PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:27523608, PubMed:27559085, PubMed:24726323, PubMed:24726327, PubMed:28919039). Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex (PubMed:23708998). Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex (PubMed:23746843, PubMed:23806334). OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met- 1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex (PubMed:26670046). Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis (PubMed:27523608). In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation (PubMed:27523608). Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2- dependent proinflammatory signaling (PubMed:23806334). [The UniProt Consortium]