FAM105B (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 897 Sequence: atgtaccgtg ctgcagatga aatagaaaag gagaaagaat tgcttataca tgaaagaggg gcatcagaac cgagattaag cgtagctcct gaaatggata tcatggacta ctgcaaaaaa gaatggagag gaaatacaca gaaagcaacg tgtatgaaaa tgggctatga agaggtttct cagaagttca cctccatacg gcgagtccgt ggtgataatt actgtgcact gagggccacg ctgttccagg ccatgagcca ggctgtgggg ctgccgccct ggctgcagga cccggagctc atgctgttac cagaaaaact cataagcaaa tacaactgga tcaagcaatg gaaacttgga ctgaaatttg atgggaagaa tgaggacctg gttgataaaa ttaaagagtc ccttactctg ctgaggaaga agtgggcagg cttggctgaa atgagaactg ctgaagcaag acagatagct tgtgatgaac tattcacaaa tgaggcggag gaatatagcc tctatgaagc tgtaaaattt ctaatgctaa acagagccat tgaactatat aatgataaag agaaaggaaa ggaagtacca tttttctctg tgcttctgtt tgctcgggac acatcaaatg acccaggaca gcttctgagg aaccacctca accaggtggg acacactggt ggtcttgaac aggttgaaat gttccttctt gcctatgctg tgcgccacac catccaggtg taccggctct ccaagtacaa cacggaagaa ttcatcacag tctaccccac cgacccaccc aaggactggc cagtggtaac gctcattgct gaggacgatc ggcactataa catccccgtc agagtgtgtg aggagaccag Protein function: Deubiquitinase that specifically removes linear ('Met-1'- linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed:26997266, PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:27523608, PubMed:27559085, PubMed:24726323, PubMed:24726327, PubMed:28919039). Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex (PubMed:23708998). Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex (PubMed:23746843, PubMed:23806334). OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met- 1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex (PubMed:26670046). Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis (PubMed:27523608). In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation (PubMed:27523608). Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2- dependent proinflammatory signaling (PubMed:23806334). [The UniProt Consortium]