EYA3 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 1611 Sequence: atggaagaag agcaagattt accagagcaa ccagtgaaaa aagccaagat gcaggaatca ggagagcaaa ctataagtca agtaagcaat ccagatgtca gtgatcagaa gcctgaaaca tcaagccttg cttcaaacct tcccatgtca gaggaaatta tgacatgcac cgattacatc cctcgctcat ccaatgatta tacctcacaa atgtattctg caaaacctta tgcacatatt ctctcagttc ctgtttcgga aactgcttac cctggacaga ctcaatacca gacactacag cagactcaac cctatgctgt ctaccctcag gcaacccaaa cgtatggact acctcctttt gcttcaagca caaatgccag cctgatatct acttcttcta caattgccaa tattccagca gcagcagtag ccagcatctc aaaccaggat tatcccacct atactattct tggtcagaat cagtaccagg cctgctaccc cagctccagc tttggagtca caggtcagac taacagtgat gcagagagca ccacattagc agcaaccaca taccagtcgg agaagcctag tgtcatggcg cctgcacctg cagcacagag actttcctct ggagaccctt ctacaagtcc atctttgtcc cagactacac caagtaaaga tactgatgat cagtccagga aaaacatgac tagcaagaac cggggcaaga ggaaagctga tgccacttct tcccaagaca gtgaattaga acgggtattt ctgtgggact tggatgaaac catcatcatc ttccactcac ttcttactgg atcctatgcc cagaaatatg gaaaggaccc aacagtagtg attggctcag gtttaacaat ggaagaaatg atttttgaag tggctgatac tcatctattt ttcaatgact tagaggagtg tgaccaggta catgtggaag atgtggcttc tgatgacaat ggccaagact tgagcaacta cagtttctca acagatggtt tcagtggctc aggaggtagt ggcagccatg gttcatctgt gggtgttcag ggaggtgtgg actggatgag gaaactagct ttccgctacc ggaaagtgag agaaatctat gataagcata aaagcaacgt gggtggtctc ctcagtcccc agaggaagga agcactgcag agattaagag cagaaattga agttttaaca gattcctggt taggaactgc attaaagtcc ttacttctca tccagtccag aaagaattgt gtgaatgttc tgatcactac cacccagctg gttccagccc tggccaaggt tctcctatat ggactaggag aaatatttcc tattgagaac atctatagtg ctaccaaaat tggtaaggag agctgctttg agagaattgt gtcaaggttt ggaaagaaag tcacatatgt agtgattgga gatggacgag atgaagaaat tgcagccaaa cagcaactct atttcttaga catggaggca ttgggttgcc agctagaacc aactgccctg atactcttca tccagttaag tggaaacctt agcaactata ataaactatg Protein function: Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1- DACH1 complex and seems to be dependent on EYA3 phosphatase activity. May be involved in development of the eye. [The UniProt Consortium]