EYA1 (Vector pUC, Accession No. BC121799)

Length: 1779 Sequence: ATGGAAATGC AGGATCTAAC CAGCCCGCAT AGCCGTCTGA GTGGTAGTAG TGAATCCCCC AGTGGCCCCA AACTCGGTAA CTCTCATATA AATAGTAATT CCATGACTCC CAATGGCACC GAAGTTAAAA CAGAGCCAAT GAGCAGCAGT GAAACAGCTT CAACGACAGC CGACGGGTCT TTAAACAATT TCTCAGGTTC AGCAATTGGG AGCAGTAGTT TCAGCCCACG ACCAACTCAC CAGTTCTCTC CACCACAGAT TTACCCTTCC AACAGACCAT ACCCACATAT TCTCCCTACC CCTTCCTCAC AAACTATGGC TGCATATGGG CAAACACAGT TTACCACAGG AATGCAACAA GCTACAGCCT ATGCCACGTA CCCACAGCCA GGACAGCCGT ACGGCATTTC CTCATATGGT GCATTGTGGG CAGGCATCAA GACTGAAGGT GGATTGTCAC AGTCTCAGTC ACCTGGACAG ACAGGATTTC TCAGCTATGG CACAAGCTTC AGTACCCCTC AACCTGGACA GGCACCATAC AGCTACCAGA TGCAAGGTAG CAGTTTTACA ACATCATCAG GAATATATAC AGGAAATAAT TCACTCACAA ATTCCTCTGG ATTTAATAGT TCACAGCAGG ACTATCCGTC TTATCCCAGT TTTGGCCAGG GTCAGTACGC ACAGTATTAT AACAGCTCAC CGTATCCAGC ACATTATATG ACCAGCAGCA ACACCAGCCC AACGACACCA TCCACCAATG CCACTTACCA GCTTCAAGAA CCGCCATCTG GCATCACCAG CCAAGCAGTT ACGGATCCCA CAGCAGAGTA CAGCACAATC CACAGCCCAT CAACACCCAT TAAAGATTCA GATTCTGATC GATTGCGTCG AGGTTCAGAT GGGAAATCAC GTGGACGGGG CCGAAGAAAC AATAATCCTT CACCTCCCCC AGATTCTGAT CTTGAGAGAG TGTTCATCTG GGACTTGGAT GAGACAATCA TTGTTTTCCA CTCCTTGCTT ACTGGGTCCT ACGCCAACAG ATATGGGAGG GATCCACCCA CTTCAGTTTC CCTTGGACTG CGAATGGAAG AAATGATTTT CAACTTGGCA GACACACATT TATTTTTTAA TGACTTAGAA GAATGTGACC AAGTCCATAT AGATGATGTT TCTTCAGATG ATAACGGACA GGACCTAAGC ACATATAACT TTGGAACAGA TGGCTTTCCT GCTGCAGCAA CCAGTGCTAA CTTATGTTTG GCAACTGGTG TACGGGGCGG TGTGGACTGG ATGAGAAAGT TGGCCTTCCG CTACAGACGG GTAAAAGAGA TCTACAACAC CTACAAAAAT AATGTTGGAG GTCTGCTTGG TCCAGCTAAG AGGGAAGCCT GGCTGCAGTT GAGGGCCGAA ATTGAAGCCC TGACCGACTC CTGGTTGACA CTGGCCCTGA AAGCACTCTC GCTCATTCAC TCCCGGACAA ACTGTGTGAA TATTTTAGTA ACAACTACTC AGCTCATCCC AGCATTGGCG AAAGTCCTGC TGTATGGGTT AGGAATTGTA TTTCCAATAG AAAATATTTA CAGTGCAACT AAAATAGGAA AAGAAAGCTG TTTTGAGAGA ATAATTCAAA GGTTTGGAAG AAAAGTGGTG TATGTTGTTA TAGGAGATGG TGTAGAAGAA GAACAAGGAG CAAAAAAGCA CGCGATGCCC TTCTGGAGGA TCTCCAGCCA CTCGGACCTC ATGGCCCTGC ACCATGCCTT GGAACTGGAG Protein function: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19234442). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears. Together with SIX1, it plays an important role in hypaxial muscle development, in this it is functionally redundant with EYA2. [The UniProt Consortium]