EXOSC8 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 831 Sequence: atggcggctg ggttcaaaac cgtggaacct ctggagtatt acaggagatt tctgaaagag aactgccgtc ctgatggaag agaacttggt gaattcagaa ccacaactgt caacatcggt tcaattagta ccgcagatgg ttctgcttta gtgaagttgg gaaatactac agtaatctgt ggagttaaag cagaatttgc agcaccatca acagatgccc ctgataaagg atacgttgtt cctaatgtgg atctaccacc cctgtgttca tcgagattcc ggtctggacc tcctggagaa gaggcccaag tggctagcca attcattgca gatgtcattg aaaattcaca gataattcag aaagaggact tatgcatttc tccaggaaag cttgtctggg ttctatactg tgatctcatt tgcctcgact acgatggaaa cattttggat gcctgcacat ttgctttgct agcggcttta aaaaatgtac agttgcctga agttactata aatgaagaaa ctgctttagc agaagttaat ttaaagaaga aaagttattt gaatattaga actcatccag ttgcaacttc ctttgctgtg tttgatgaca ctttgcttat agttgaccct actggagagg aggaacatct ggcaacagga accttaacaa tagtaatgga tgaggaaggc aaactctgtt gtcttcacaa accaggtgga agtgggctaa ctggagctaa acttcaggac tgtatgagcc gagcagttac aagacacaaa gaagttaaaa aactgatgga tgaagtaatt aagagtatga aacccaaata Protein function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs. [The UniProt Consortium]