EXOSC5 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 708 Sequence: atggaggagg agatgcatac tgacgccaaa atccgtgctg aaaatggaac agggtccagc cctcggggtc ctggctgcag cctccggcac tttgcctgcg aacagaacct gctgtcgcgg ccagatggct ctgcttcctt cctgcaaggt gacacctctg tcctggcggg tgtgtacggg ccggccgagg tgaaggtcag caaagagatt ttcaacaagg ccacactcga agtgatcctg aggccgaaga ttgggctgcc tggtgttgca gagaagagcc gggagcggct gatcaggaac acgtgcgagg cggtggtgct gggcacgttg cacccccgca cctccatcac cgtggtgctg caggttgtca gcgatgccgg ctctctcctg gcctgttgtc tgaatgccgc ctgcatggca ttggtggatg caggtgtgcc catgcgggct ctcttctgtg gggtcgcctg cgccctggac tctgatggga ccctcgtgct ggatcctaca tccaagcaag aaaaggaggc ccgggcagtc ctgacctttg ccctggacag cgtggaacgg aagctgctga tgtccagcac caaggggctc tactcagaca ctgagctcca gcagtgcctg gctgcggccc aggccgcttc gcaacacgtc ttccgtttct accgggaatc gctgcagagg cgttactcca Protein function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. [The UniProt Consortium]