EPC1 (Vector pUC, Accession No. BC036529)

Length: 2442 Sequence: atgagtaaac tgtcgtttcg ggcgcgggcg ctagacgcct cgaagccgct gccggttttc cgctgtgagg atctgcccga cctgcacgaa tacgcctcga taaacagggc cgtgccgcag atgcccaccg gaatggagaa ggaagaggag tcggaacatc atcttcagcg ggctatttca gcacagcagg tgtatggcga gaagagggat aatatggtta taccggtccc agaggcagaa agtaatattg cttactatga gtctatatat cctggggaat ttaagatgcc aaagcagctc attcacatac agccttttag tttggatgct gaacagcctg attatgattt ggattctgaa gatgaagtat ttgtgaataa actgaaaaag aaaatggaca tctgcccatt gcaatttgag gagatgattg accgcctaga aaaaggcagt ggtcagcagc cagtcagtct gcaggaagcc aaactactgc taaaagaaga tgatgaacta attagagaag tttatgaata ttggattaaa aagagaaaaa actgtcgagg gccatctctt attccatcag taaaacaaga gaagcgagat ggttccagca caaatgatcc ttatgtggct tttagaaggc gtactgaaaa aatgcagact cgaaaaaatc gcaaaaatga tgaagcctct tacgaaaaaa tgcttaagct gcgacgagat ctaagtcgag ctgttactat tctagagatg ataaaaagaa gagaaaaaag taaaagagag ctattgcact taacactgga aattatggaa aagaggtata atttgggcga ctacaatgga gagatcatgt ctgaggttat ggcacagaga cagccaatga aacctactta tgccatcccc atcatcccta ttactaatag cagtcaattt aaacaccagg aagcaatgga tgtgaaggag ttcaaagtta ataagcaaga taaagccgat cttatccgac cgaaacggaa atatgaaaag aagcccaaag tcttaccatc gtctgccgct gctactcccc aacagacgag tcctgctgca ctgccagtct tcaatgctaa agatctgaat cagtatgact ttcccagctc agacgaagaa cctctctccc aggttttgtc tggctcttcg gaagctgagg aagacaatga tcctgatggt ccttttgctt tccgtaggaa agcaggctgt cagtactatg ctcctcactt agaccaaact ggcaactggc cttggactag tcctaaagat ggaggattag gggatgtgcg atatagatac tgcttaacta ctctcaccgt accccaaagg tgtattggat ttgcacgaag acgggttggg cgcggtggaa gggtcttact ggacagagct cattcagact atgacagtgt gtttcaccat ctggatttgg aaatgctttc ctcaccacaa cattctccag tcaatcagtt tgccaatacc tcagaaacaa atacctcgga caaatctttc tctaaagacc tcagtcagat actagtcaat atcaaatcat gtagatggcg gcattttagg cctcggacac catccctaca tgacagtgac aatgatgaac tctcctgtag aaaattatat aggagtataa accgaacagg aacagcgcaa cctgggaccc agacatgcag tacctctacg caaagtaaaa gtagcagtgg ttcagcacac tttgcattta cagccgaaca ataccagcaa catcaacagc aactggcact catgcagaaa cagcagcttg cacaaattca gcaacagcaa gcaaatagta attcctccac caacacatca cagggttttg tttctaagac tttggattct gctagtgcac agtttgctgc ttctgctttg gtgacatcag aacaactgat gggattcaag atgaaggatg atgtggtgct tggaatcggg gtgaatggcg tccttccagc ctcaggagta tacaagggct tacacctcag tagtactaca ccaacagcac ttgtacatac aagtccatca acggcaggtt cagctttgtt acagccttca aatattacac agacttcaag ttcccacagt gcactgagtc atcaagtaac tgctgccaat tctgcaacaa ctcaggttct gattgggaac aacattcgat taactgtacc ttcatcagtt gccactgtaa actctattgc cccaataaat gcacgacata tacctaggac tttaagtgtt gttccatcat ctgccttaaa gctggccgct gcagcaaact gtcaagtttc caaggtccca tcttcatcct ctgtagattc agttccaagg gaaaatcatg aatcagaaaa gccagcactg aacaacatag cagacaacac agtagcgatg gaggtgacgt Protein function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. [The UniProt Consortium]