ENY2 (Vector pENTR223.1, Accession No. BC007870)

Length: 306 Sequence: atggtggtta gcaagatgaa caaagatgcg cagatgagag cagcgattaa ccaaaagttg atagaaactg gagaaagaga acgcctcaaa gagttgctga gagctaaatt aattgaatgt ggctggaagg atcagttgaa ggcacactgt aaagaggtaa ttaaagaaaa aggactagaa cacgttactg ttgatgactt ggtggctgaa atcactccaa aaggcagagc cctggtacct gacagtgtaa agaaggagct cctacaaaga ataagaacat tccttgctca gcatgccagc Protein function: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor- mediated transactivation (PubMed:18206972, PubMed:21746879). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:23591820). [The UniProt Consortium]