ELL3 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 1194 Sequence: atggaggagc tccaggagcc tctgagagga cagctccggc tctgcttcac gcaagctgcc cggactagcc tcttactgct caggctcaac gacgctgccc tgcgggcgct gcaagagtgt cagcggcaac aggtacggcc ggtgattgct ttccaaggcc accgagggta tctgagactc ccaggccctg gttggtcctg cctcttctcc ttcatagtgt cccagtgttg tcaggagggc gctggtggta gcttggacct tgtgtgccaa cgcttcctca ggtctgggcc taacagcctc cactgcctgg gctcactcag ggagcgcctc attatttggg cagccatgga ttctatccca gccccatcat cagttcaggg acacaacctg actgaagatg ccagacatcc tgagagttgg cagaacacag gaggctattc tgaaggagat gcagtatcac agccacagat ggcactagag gaggtgtcag tgtcagatcc actggcaagc aaccaaggac agtcactccc aggatcctca agggagcaca tggcacagtg ggaagtgaga agccagaccc atgttccaaa cagagaacct gttcaggcac tgccttcctc tgccagccgg aaacgtctgg acaagaaacg ttcagtgcct gtagccactg tagaactgga agaaaagagg ttcagaactc tgcctttagt gccaagcccc ctacaaggcc tgaccaatca ggatttacaa gagggagaag attgggagca agaagatgag gacatggacc ccagattaga acacagttcc tcagttcaag aagattctga atccccaagt cctgaagata taccagacta cctcctgcaa tacagggcca tccacagtgc agaacagcaa catgcctatg agcaggactt tgagacagat tatgctgaat accgcatcct gcatgcccgt gttgggactg caagccaaag gttcatagag ctgggagcag agattaaaag agttcggcga ggaactccag aatacaaggt cctggaagac aagataatcc aggaatataa aaagttcagg aagcagtacc caagttacag agaagaaaag cgtcgctgtg agtaccttca ccagaaattg tcccacatta aaggtctcat cctggagttt gaggaaaaga acaggggcag Protein function: Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial- mesenchymal transition (EMT). Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). [The UniProt Consortium]