EIF3I (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 978 Sequence: atgaagccga tcctactgca gggccatgag cggtccatta cgcagattaa gtataaccgc gaaggagacc tcctctttac tgtggccaag gaccctatcg tcaatgtatg gtactctgtg aatggtgaga ggctgggcac ctacatgggc cataccggag ctgtgtggtg tgtggacgct gactgggaca ccaagcatgt cctcactggc tcagctgaca acagctgtcg tctctgggac tgtgaaacag gaaagcagct ggcccttctc aagaccaatt cggctgtccg gacctgcggt tttgactttg ggggcaacat catcatgttc tccacggaca agcagatggg ctaccagtgc tttgtgagct tttttgacct gcgggatccg agccagattg acaacaatga gccctacatg aagatccctt gcaatgactc taaaatcacc agtgctgttt ggggacccct gggggagtgc atcatcgctg gccatgagag tggagagctc aaccagtata gtgccaagtc tggagaggtg ttggtgaatg ttaaggagca ctcccggcag atcaacgaca tccagttatc cagggacatg accatgtttg tgaccgcgtc caaggacaac acagccaagc tttttgactc cacaactctt gaacatcaga agactttccg gacagaacgt cctgtcaact cagctgccct ctcccccaac tatgaccatg tggtcctggg cggtggtcag gaagccatgg atgtaaccac aacctccacc aggattggca agtttgaggc caggttcttc catttggcct ttgaagaaga gtttggaaga gtcaagggtc actttggacc tatcaacagt gttgccttcc atcctgatgg caagagctac agcagcggcg gcgaagatgg ttacgtccgt atccattact tcgacccaca gtacttcgaa tttgagtttg Protein function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl- tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). [The UniProt Consortium]