EFHA1 (Vector pUC, Accession No. BC034965)

Length: 1305 Sequence: atggcggcgg ctgcgggtag ctgcgcgcga gtggcggcct ggggcggaaa actgcgacgg gggctcgctg tcagccgaca ggctgtgcgg agtcccggcc ccttggcagc ggcagtggcc ggcgcggccc tggcaggagc aggagcggcc tggcaccaca gccgcgtcag tgttgcggcg cgggatggca gttttacagt ctccgcacag aaaaatgttg aacatggaat aatatatatt gggaaaccgt ctcttcgtaa gcagcgcttc atgcagtttt cttcactcga acatgaagga gaatattata tgacaccacg agacttcctc ttctcagtga tgtttgagca aatggaacgt aaaacttcag tcaagaagct gacaaaaaag gacatcgagg atacactgtc agggatccaa acagctggct gtggatcaac ttttttcaga gaccttggcg ataaagggct aatttcatat accgagtatc ttttcttgct tacaatcctc actaaacccc attctggatt tcatgttgct tttaaaatgc tggatacaga tggtaatgag atgattgaaa aaagggaatt ttttaagctg cagaagatca taaataaaca agatgacttg atgacagtga aaactaatga aactggatat caggaagcaa tagtgaaaga acctgaaatt aacacaactc ttcagatgcg tttctttgga aaaagaggac aaagaaaact tcattataaa gaatttcgaa gatttatgga aaatttacta acagagattc aagaaatgga attccttcag ttttctaaag gtttgagttt catgagaaaa gaagactttg cagagtggct actttttttc actaacactg aaaataaaga tatttattgg aaaaatgtga gagagaagtt gtcagcagga gagagcatta gtttggatga attcaagtca ttttgccatt ttacaaccca cttggaagac tttgctattg ccatgcagat gttcagttta gctcatcgtc ctgtcagact agcggagttt aagagagctg tgaaagtagc aacaggacaa gaactctcaa acaatatttt ggacactgtc tttaagatct ttgatttgga tggtgatgaa tgtcttagtc atgaagagtt tcttggggtg ttaaaaaaca gaatgcatcg aggtttatgg gtaccacaac atcagagtat acaagaatac tggaagtgtg tgaagaaaga aagcattaaa ggagtaaaag aagtctggaa acaagctgga aaaggtcttt Protein function: Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:24503055, PubMed:24560927, PubMed:26903221). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF- hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering (PubMed:24560927). [The UniProt Consortium]