EFCAB4B (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 1188 Sequence: atggctgccc ctgacgggag ggtagtctcc agaccccaga gacttggtca ggggtctggc caggggccaa aggggagtgg agcctgcctg catcccctgg acagcctgga gcagaaggag actcaggagc aaacgtcggg ccagctagtc atgctgagga aggcacagga gttctttcag acctgtgatg ctgaaggcaa gggcttcatc gccaggaagg atatgcagag gctgcataag gagctaccgc tcagcctgga ggaactggag gatgtgtttg atgccctgga tgctgatggc aatggctatc tgaccccaca ggagttcact actggattta gtcacttctt cttcagccag aataacccaa gtcaggaaga tgcaggtgaa caggtggccc agcgccatga agagaaggtg tatctgtcca gaggggatga ggatctgggc gacatgggcg aagatgagga agcccagttc cggatgctga tggacagact tggagcccaa aaggtgttgg aagatgaaag tgatgtcaag cagctctggt tgcagctgaa gaaggaggaa cctcatttac tgtccaactt tgaagacttc ctgaccagaa tcatctccca gctccaagaa gcccatgagg agaagaatga actggagtgt gccctaaaaa ggaaaattgc tgcttatgat gaagaaatcc agcatctcta tgaggagatg gaacaacaaa tcaaaagtga gaaggagcag tttctcctga aggacacaga gaggtttcaa gcccgcagtc aagagctgga gcagaaactg ttatgtaagg agcaggagct ggagcagctc acccagaagc agaaaaggct ggaaggtcag tgcacagccc tgcatcatga caagcatgag accaaggctg agaataccaa gctgaaactc actaaccagg agctggcccg ggagctggag cggacttcct gggagctcca ggatgctcag cagcagttgg aaagcctcca gcaagaggcc tgcaaactcc accaagagaa ggagatggaa gtgtaccgtg tgacggagag tctacagcgt gagaaggccg ggctcctcaa gcagctggat ttcctaaggt gcgtcggtgg gcactggcct gtgctgagag cacctcccag aagcctgggg tcggaaggac Protein function: [Isoform 1]: Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. [The UniProt Consortium]