DTX2 (Vector pUC, Accession No. BC018555)

Length: 1869 Sequence: atggccatgg ccccaagccc ttccctggtg caggtgtaca ccagccccgc ggctgtggcc gtgtgggaat ggcaggacgg gctgggcacc tggcacccct acagtgccac cgtctgcagc ttcatcgagc agcagtttgt ccagcagaag ggccaacgtt ttgggcttgg gagcctggcc cacagcatcc ccttgggcca ggcagacccc tcgctggccc cttacattat tgacctcccc agctggaccc agttccgcca ggacaccggc accatgcggg ctgtgcggag acacctgttc ccccagcact cagcccctgg ccgaggtgtc gtctgggagt ggctgagcga cgatggctcc tggactgcct atgaagccag cgtctgtgac tatctggagc agcaggtggc caggggcaac cagctcgtgg acttggcccc cctggggtac aactacactg tcaactacac cacccacacg cagaccaaca agacttccag cttttgccgc agcgtgcggc gccaagcagg gccgccttac ccggtgacca ccatcatcgc tccgccgggc cacacaggcg tcgcctgctc ttgccaccag tgcctcagtg gcagcagaac tggccccgtg tcaggccgct accgccactc catgaccaac ctccctgcat accccgtccc ccagcacccc ccacacagga ccgcttctgt gtttgggacc caccaggcct ttgcaccgta caacaaaccc tcactctccg gggcccggtc tgcgcccagg ctgaacacca ccaacgcctg gggcgcagct cctccttccc tggggagcca gcccctctac cgctccagcc tctcccacct gggaccgcag cacctgcccc caggatcctc cacctccggt gcagtcagtg cctccctccc cagcggtccc tcaagcagcc cagggagcgt ccctgccact gtgcccatgc agatgccaaa gcccagcaga gtccagcagg cgctcgcagg catgacgagt gttctgatgt cagccattgg actccctgtg tgtcttagcc gcgcacccca gcccaccagc cctcccgcct cccgtctggc ttccaaaagt cacggctcag ttaagagatt gaggaaaatg tccgtgaaag gagcgacccc gaagccagag ccagagccag agcaggtcat aaaaaactac acggaagagc tgaaagtgcc cccagatgag gactgcatca tctgcatgga gaagctgtcc gcagcgtctg gatacagcga tgtgactgac agcaaggcaa tcgggtccct agctgtgggc cacctcacca agtgcagcca tgccttccac ctgctgtgcc tcctggccat gtactgcaac ggcaataagg atggaagtct gcagtgtccc tcctgcaaaa ccatctatgg agagaagacg gggacccagc cccagggaaa gatggaggta ttacggttcc agatgtcgct ccccggccac gaggactgcg ggaccatcct catagtttac agcattcccc atggtatcca gggccctgag caccccaatc ccggaaagcc gttcactgcc agagggtttc cccgccagtg ctaccttcca gacaacgccc agggccgcaa ggtcctagag ctcctgaagg tggcctggaa gaggcggctc atcttcacag tgggcacgtc cagcaccacg ggtgagacgg acaccgtggt atggaacgag atccaccaca agacagagat ggaccgcaac attacgggcc acggctatcc cgaccccaac tacctgcaga acgtgctggc tgagctggct gcccaggggg tgaccgagga ctgcctggag Protein function: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. [The UniProt Consortium]