DOHH (Vector pUC, Accession No. BC002817)

Length: 909 Sequence: atggtgacgg agcaggaggt ggatgccatc gggcagacgc tggtggaccc caagcagccc ctgcaggccc gcttccgggc gctgttcacg ctgcgtgggc tcggcggccc aggcgccatt gcatggatca gccaggcctt cgatgacgat tccgccctgc tcaagcacga gctggcctac tgcctgggcc agatgcagga tgcccgcgcc atccccatgc tggtggacgt gctgcaagac acccgtcagg agcccatggt gcgccatgag gcaggggagg ccctgggggc catcggggac ccggaagttc tggagatcct gaagcagtat tcctcggacc ccgtcatcga ggtggccgag acctgccagc tggccgtgcg caggctggag tggctgcagc agcacggcgg ggagccggcg gcgggaccct acctctccgt ggaccctgcc ccgccggctg aggagcgtga cgtggggcgc ctgcgggagg cgctgctgga tgagtcccgg ccgctcttcg agcgataccg cgccatgttc gccctgcgca acgcgggagg cgaggaggcc gccctggcgc tggccgaggg tctgcactgt gggagcgccc tcttccgcca cgaggtcggc tacgtcctgg gacagctgca gcacgaggcg gcggtgcccc agctggcggc cgccctggcc cgatgcaccg agaaccccat ggtgcggcac gagtgcgcgg aggccctggg cgccattgcc cggcccgcct gcctggccgc gctgcaggct cacgcggacg acccagagcg cgtggtgcgt gagagctgcg aggtggctct ggacatgtat gagcacgaga ccgggcgggc cttccagtac gcggacggcc tggagcagct gcgcggggcc Protein function: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF- 5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine (PubMed:16533814, PubMed:16371467, PubMed:19706422). Hypusination is unique to mature eIF-5A factor and is essential for its function. [The UniProt Consortium]