DOCK8 (Vector pUC, Accession No. BC130518)

Length: 6000 Sequence: atgacacacc tgaacagcct ggatgtgcag cttgcccagg agctcgggga cttcactgat gacgacttgg acgtggtgtt cacgccaaag gaatgtagga ctttgcagcc ctctttgccg gaggaagggg ttgaactgga ccctcatgtc agggactgtg ttcagaccta catccgtgag tggctaatcg tgaaccggaa aaaccaagga agtccagaaa tctgtggctt taaaaagact ggatctcgaa aagattttca caagacgctt ccgaaacaga cgtttgagtc ggaaaccttg gagtgcagtg aacccgctgc tcaggcaggc ccccgccact taaacgtgct gtgcgacgtg tctgggaaag gccccgtcac tgcctgtgac tttgacctcc gcagcctgca gcctgacaag cggctagaaa acctcctgca gcaagtgagt gccgaggact ttgagaagca gaacgaggag gcccggagga ccaataggca ggccgagctc tttgcccttt acccatcagt ggacgaggag gatgctgtgg aaatacgtcc agtaccagaa tgtcccaagg aacacctggg caacagaata ttggtcaagt tgctgacctt gaagttcgag attgaaattg agcccctgtt tgccagcatt gccctctacg atgttaaaga aaggaaaaag atctcagaaa attttcactg tgacctgaac tctgaccagt tcaaaggatt tctgcgagct cacacgcctt cagtggccgc atcaagtcag gcgagatctg cagtcttctc agtcacctac ccgtcctcag acatctacct ggtagtcaag attgaaaaag tcctgcagca gggagagatt ggagactgtg cagagcccta cacggttatc aaagaaagtg atggtggaaa gagtaaagaa aagattgaaa aactaaaact ccaagctgaa tccttctgcc agcgtttggg gaaataccgg atgccctttg cctgggcacc cataagctta tcaagcttct tcagtgtctc cacccttgag agggaggtaa ctgatgtgga ctctgtggtt gggagaagct cagtgggtga acggaggaca ttggcccaat ctagaaggct ttctgaaaga gccctctcct tggaggaaaa tggggttgga tccaacttca aaacctccac tctgagcgtt agcatctttt tcaagcagga aggagatcgc cttagcgatg aagacttatt caagttttta gctgactaca aaagatcatc atccttacag agacgagtca agtcaattcc aggcttgcta agactggaga tttctacagc tccagagatc atcaattgct gtctgactcc tgaaatgctg cccgtgaaac cctttcctga aaaccggaca cgcccgcaca aagagatttt ggaatttcca acacgagaag tatatgtccc tcacactgtg tacagaaacc ttctctatgt ctacccacag aggctgaact ttgtaaacaa actagcatca gcccggaaca ttacaataaa gatccagttt atgtgtggag aagatgctag caatgcgatg ccggtcatct ttggaaagtc cagcgggcct gaatttctgc aggaagtgta cacagctgtt acataccata ataagtctcc tgacttttat gaagaagtga aaattaagct ccccgctaag ctcacagtaa atcaccacct cctgttcacc ttctaccata tcagctgtca gcagaagcaa ggagcctccg tggaaactct cctgggatat tcatggctgc caattctctt aaatgaacgt cttcaaactg gatcctactg tctcccagtt gccttggaaa aattgccacc caactactcc atgcattctg ctgagaaagt cccattacag aatcctccca ttaagtgggc tgaaggacat aagggagtat ttaatattga agtgcaagct gtttcttctg tacacaccca ggacaaccac ctggagaagt tcttcaccct ctgccactcc ctggagagcc aggtgacctt ccccatccgc gtgctggatc agaaaatcag cgagatggcg ctggagcatg agctgaagct cagcatcatc tgcctcaact cctcccgcct ggagccgctc gtgctcttcc tgcacctggt gctggacaag ctcttccagc tgtccgtgca gcccatggtc atcgctggcc agacagccaa cttctcccag tttgccttcg agtccgtggt ggccatcgcc aacagtctgc acaacagcaa ggacctgagc aaggaccagc atgggaggaa ctgcctgctg gcttcctacg tgcactacgt cttccgcctg ccagaggtgc aaagggatgt gcccaagtca ggcgctccca ctgccctcct agaccctcgg agctaccaca cgtatggccg cacatcagct gctgctgtga gttcaaagct gctgcaggcc cgggtgatga gcagcagtaa cccagacctc gcggggacac actccgcagc agacgaggaa gtgaagaaca tcatgtcttc aaagcatttc catgaggagc ttgcccttca gatggtggtc agcactggaa tggtgagaga aacagtcttc aagtatgcct ggttcttctt tgagcttctg gtgaaaagca tggcccagca cgtacataac atggacaaac gggacagttt tcggaggact cgtttttctg accgtttcat ggatgacata actactattg ttaatgtggt cacctcggaa attgcagccc ttttagtaaa accacagaag gaaaatgaac aggcggaaaa gatgaacatc agcctggctt tcttcttgta tgaccttctc tccctcatgg atcggggctt tgtgtttaac ctcatcagac attattgcag ccagctgtca gccaagctca gtaaccttcc aacgctcatt tccatgaggc tagagttcct gagaatcctc tgtagccatg agcattacct caatctgaac ctttttttta tgaatgctga tactgctcca acatctcctt gtccttccat atcttcccag aactcaagct cctgctccag cttccaggac cagaagatcg ccagcatgtt cgatctgact tccgagtacc gccagcagca cttcctcacc gggctcctct tcacagaact ggctgctgcc ctggatgccg aaggggaagg aatcagcaaa gtacaaagga aagctgtcag tgcaattcac agcctgctaa gttctcacga cctggaccca cgctgtgtca aaccagaggt gaaggtcaaa atcgccgccc tttacctacc tttagttggc atcattttgg atgctttgcc acagctctgt gactttacag ttgcagatac tcgcagatac cgcaccagtg gctcggatga agaacaagaa ggagccggtg ccattaacca gaatgtggct ctggccatag cagggaataa tttcaatttg aaaacaagtg gaatagtgct gtcttccttg ccctataagc agtacaacat gctgaacgcg gacactactc gcaacctcat gatctgcttc ctctggatca tgaaaaatgc tgatcagagc ctcattagga agtggattgc tgacctgcca tcaacgcagc tcaacaggat tttagatcta cttttcatct gtgtgttatg ttttgagtat aagggaaaac agagttctga caaagtcagt acccaagtcc tgcagaagtc aagggatgtc aaggcccggc tggaagaggc tttgctccgt ggggaagggg ccagagggga gatgatgcgc cgccgggctc cagggaacga ccgatttcca ggcctaaatg aaaatttgag atggaagaaa gagcagacac attggcggca agctaatgag aagctagata aaacaaaggc cgagttagat caagaagcct tgatcagtgg caatctggct acagaagcac atttaatcat cctggatatg caggaaaaca ttatccaggc gagctcggct ctggactgta aagacagcct gctgggaggt gttctgaggg tgctggtgaa ttctctgaac tgtgatcaga gtaccaccta cctgactcac tgctttgcaa cactccgtgc tctcatcgcc aagtttggag acttactctt cgaagaggag gtggaacagt gtttcgacct atgtcaccaa gtcctgcacc actgcagcag cagcatggat gtcacccgga gccaagcctg tgccaccctt tacctcctca tgaggttcag ttttggagcc accagtaatt ttgcaagagt aaagatgcaa gtaaccatgt ccctggcatc tttggtggga agagcaccag actttaatga agagcacctg agaagatcct tgaggacaat tttggcctat tcagaagagg acacagccat gcagatgact ccttttccca cccaggtgga ggaacttctc tgtaatctga atagcatctt atatgacaca gtgaaaatga gggaatttca ggaagatcct gagatgctta tggatctcat gtacagaatt gccaagagtt accaggcatc tcctgatctg cggctgacct ggctccagaa catggcagag aaacacacca agaagaagtg ctacacggag gctgccatgt gcctggtgca cgccgctgcg ttagtggctg agtatctgag catgctggag gaccacagct acctgcccgt gggcagtgtc agcttccaga atatttcttc caatgtgctg gaggagtctg tggtctctga ggacaccctg tcacctgacg aggatggggt gtgcgcaggc cagtacttca ccgagagtgg cctggtaggc ctcctggagc aggccgcgga gctcttcagc acgggaggct tatatgagac agttaatgag gtctacaagc tggtcatccc catcctagaa gcgcatcgag aattccggaa gctgacactc actcacagca agctgcagag agccttcgac agcatcgtta acaaggatca taagagaatg tttggaacct acttccgagt tggtttcttt ggatccaaat ttggggattt ggatgaacag gaatttgtct acaaagagcc tgcaattacc aagcttcctg agatctcaca tagactagag gcattttatg gtcaatgttt tggtgcagaa tttgtggaag tgattaaaga ctccactcct gtggacaaaa ccaagttgga tcctaacaag gcctacatac agatcacttt tgtggagccc tactttgatg agtatgagat gaaagacagg gtcacatact ttgagaagaa tttcaacctc cggaggttca tgtacaccac cccgttcacc ctggaggggc ggcctcgggg agagctgcat gagcagtaca gaaggaacac agtcctgacc actatgcacg ccttcccctt catcaagacc aggatcagcg tcatccagaa ggaggagttt gttttgacac cgattgaagt tgccattgaa gacatgaaga agaagaccct gcagttagca gttgccatta accaggagcc gcctgatgca aagatgcttc agatggtgct gcaaggctct gtgggagcta ctgtaaatca gggaccactg gaagtagccc aagtgttttt ggctgaaatt cctgctgatc caaaactcta tcgacatcac aacaagttga ggttatgctt taaggaattc atcatgagat gtggtgaagc tgtagagaaa aacaagcgtc tcatcacggc agaccagagg gaatatcagc aggaactcaa aaagaactat aacaagctaa aagagaacct caggccaatg atcgagcgga aaattccaga actgtacaag ccaatattca gagttgagag tcaaaagagg gactccttcc acagatctag tttcaggaaa tgtgaaaccc agttgtcaca Protein function: Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151, PubMed:22461490). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780). [The UniProt Consortium]