DOCK10 (Vector pENTR223.1, Accession No. BC015018)

Length: 1629 Sequence: atgaaaaaca gcaatttccc agcagaggtg aaggacctga ctaagcgtat aaggactgtt ttgatggcca cagctcagat gaaggagcac gagaaggacc ccgagatgct ggtggatctc cagtacagcc tggcaaactc ctacgcaagc actcctgaac tacgcaggac ctggctggaa agtatggcca agattcatgc cagaaacgga gatttatctg aggctgccat gtgttacatc catattgctg ctctcattgc agagtatctg aaaagaaagg gttactggaa agtggaaaag atttgcacag catccctgct ctcggaggat acccacccct gtgatagcaa ctcattacta acaactccca gtggaggaag catgttctct atgggatggc cagctttttt gagcattaca ccaaacatta aggaagaagg agcgatgaaa gaggattctg gaatgcaaga tacaccatac aatgagaata tcctggtgga gcagctatac atgtgtgtgg agtttctctg gaagtctgag cgatatgaac tcattgctga tgtcaacaag cccatcattg ctgtctttga gaaacaacga gacttcaaaa aattgtcaga tctctactac gacattcatc ggtcatatct gaaagtggca gaggtggtga attcggagaa gcggctgttt ggtcgctact atcgtgtggc attttatggg cagggctttt ttgaagaaga agaaggtaaa gagtatattt ataaagagcc taagctgaca ggtctgtccg agatttccca aagattactc aagctctatg cagataaatt tggagcagac aatgtgaaga taatccagga ttccaacaag gtaaacccca aggatttgga ccccaaatat gcctacatcc aggtgaccta tgtgacgccg ttctttgagg aaaaggaaat cgaagaccgg aagacagatt tcgaaatgca ccacaacatc aaccgctttg tcttcgagac acccttcacg ctgtcgggca agaagcacgg tggggtggcg gagcagtgca agcggcggac gatcctgaca acgagtcacc tgttccccta cgtgaagaag agaatacaag taattagcca atcgagcaca gaactgaatc caattgaagt ggcaattgac gagatgtcca agaaggtttc tgagcttaat cagctttgca caatggaaga agtggacatg atcagactgc agctcaaact gcaaggaagt gtcagcgtga aggttaatgc tgggccaatg gcctatgcac gagcttttct tgaagaaacc aatgcaaaga agtaccctga caaccaagta aagcttttga aggagatctt caggcaattt gcagatgcat gtgggcaggc ccttgacgtg aatgagcgcc tcatcaaaga ggaccagctg gagtaccagg aagaactgag gtcccactac aaggacatgc tcagcgaact ctccacagtc atgaatgagc agattacggg cagggacgac ctgtcaaagc gcggagtgga ccaaacctgc actcgagtaa ttagcaaagc aactccggcc ctacccacgg tctccatctc atctagtgct Protein function: Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. [The UniProt Consortium]