DNAJC3 (Vector pENTR223.1, Accession No. BC047936)

Length: 1515 Sequence: atggtggccc ccggctccgt gaccagccgg ctgggctcgg tattcccctt cctgctagtc ctggtggatc tgcagtacga aggtgctgaa tgtggagtaa atgcagatgt tgagaaacat cttgaattgg gcaagaaatt acttgcagct ggacagctag ctgatgcttt atctcagttt catgctgccg tagatggtga ccctgataac tatattgctt attatcggag ggctactgtc tttttagcta tgggcaaatc aaaagctgca cttcctgatt taactaaagt gattcaattg aagatggact tcactgcagc aagattacag agaggtcact tattactcaa acaaggaaaa cttgatgaag cagaagatga ttttaaaaaa gtgctcaaat ctaatccaag tgaaaatgaa gaaaaggaag cacagtctca acttataaaa tctgatgaaa tgcagcgttt gcgttcacaa gcacttaacg cttttggaag tggagattat actgctgcta tagccttcct tgataagatt ttagaggttt gtgtttggga tgcagaacta cgggaacttc gagctgaatg ttttataaaa gaaggagaac ctaggaaagc tataagtgac ttaaaagctg cgtcaaagtt gaagaatgat aatactgaag cgttttataa aataagcaca ctgtactacc aactaggaga ccacgaactg tccctcagtg aagttcggga atgtcttaaa cttgaccagg atcataaaag gtgttttgca cactataaac aagtaaagaa acttaataag ctgattgagt cagctgaaga gctcatcaga gatggcagat acacagatgc taccagcaaa tatgaatctg tcatgaaaac agagccaagc attgctgaat atacagttcg ttcaaaggag aggatttgcc actgcttttc taaggacgag aagcctgttg aagctattag ggtttgttct gaagttttac agatggaacc tgacaatgtg aatgccctga aagatcgagc agaggcctat ttgatagagg aaatgtatga tgaagctatt caggattatg aaactgctca ggaacacaat gaaaatgatc agcagattcg agaaggtcta gagaaagcac aaagattatt gaaacagtcg cagaaacgag attattataa aatcttggga gtaaaaagaa atgccaaaaa gcaagaaatt attaaagcat accgaaaatt agcactgcag tggcacccag ataacttcca gaatgaagaa gaaaagaaaa aagctgagaa aaagttcatt gatatagcag ctgctaaaga agtcctctct gatccagaaa tgagaaagaa gtttgacgac ggagaagatc ctttggatgc agagagccag caaggaggcg gcggcaaccc tttccacaga agctggaact catggcaagg gttcaatccc ttcagctcag gcggaccatt tagatttaaa ttccacttca Protein function: Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF- 2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. [The UniProt Consortium]